[HTML][HTML] Bidirectional roles of skeletal muscle fibro-adipogenic progenitors in homeostasis and disease

W Chen, W You, TG Valencak, T Shan - Ageing Research Reviews, 2022 - Elsevier
Sarcopenia and myopathies cause progressive muscle weakness and degeneration, which
are closely associated with fat infiltration and fibrosis in muscle. Recently, experimental …

A glitch in the matrix: the pivotal role for extracellular matrix remodeling during muscle hypertrophy

CR Brightwell, CM Latham… - … of Physiology-Cell …, 2022 - journals.physiology.org
Multinuclear muscle fibers are the most voluminous cells in skeletal muscle and the primary
drivers of growth in response to loading. Outside the muscle fiber, however, is a diversity of …

Thrown for a loop: fibro-adipogenic progenitors in skeletal muscle fibrosis

T Loomis, LR Smith - American Journal of Physiology-Cell …, 2023 - journals.physiology.org
Fibro-adipogenic progenitors (FAPs) are key regulators of skeletal muscle regeneration and
homeostasis. However, dysregulation of these cells leads to fibro-fatty infiltration across …

[HTML][HTML] Unlocking the potential of stem cells: Their crucial role in the production of cultivated meat

DK Lee, M Kim, J Jeong, YS Lee, JW Yoon… - Current Research in …, 2023 - Elsevier
Cellular agriculture is an emerging research field of agribiotechnology that aims to produce
agricultural products using stem cells, without sacrificing animals or cultivating crops …

Muscle fibro-adipogenic progenitors from a single-cell perspective: Focus on their “virtual” secretome

E Negroni, M Kondili, L Muraine, M Bensalah… - Frontiers in Cell and …, 2022 - frontiersin.org
Skeletal muscle is a highly plastic tissue composed of a number of heterogeneous cell
populations that, by interacting and communicating with each other, participate to the muscle …

Radiation induces long‐term muscle fibrosis and promotes a fibrotic phenotype in fibro‐adipogenic progenitors

N Collao, D D'Souza, L Messeiller… - Journal of Cachexia …, 2023 - Wiley Online Library
Background Radiation‐induced muscle pathology, characterized by muscle atrophy and
fibrotic tissue accumulation, is the most common debilitating late effect of therapeutic …

[HTML][HTML] Single-cell RNA sequencing in skeletal muscle developmental biology

C Cai, Y Yue, B Yue - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Skeletal muscle is the most extensive tissue in mammals, and they perform several
functions; it is derived from paraxial mesodermal somites and undergoes hyperplasia and …

MuSCs and IPCs: Roles in skeletal muscle homeostasis, aging and injury

H Jiang, B Liu, J Lin, T Xue, Y Han, C Lu… - Cellular and Molecular …, 2024 - Springer
Skeletal muscle is a highly specialized tissue composed of myofibres that performs crucial
functions in movement and metabolism. In response to external stimuli and injuries, a range …

[HTML][HTML] PPARγ agonist treatment reduces fibroadipose tissue in secondary lymphedema by exhausting fibroadipogenic PDGFRα+ mesenchymal cells

Z Chen, SAA Ghavimi, M Wu, J McNamara, O Barreiro… - JCI insight, 2023 - ncbi.nlm.nih.gov
Secondary lymphedema occurs in up to 20% of patients after lymphadenectomy performed
for the surgical management of tumors involving the breast, prostate, uterus, and skin …

Muscle denervation promotes functional interactions between glial and mesenchymal cells through NGFR and NGF

C Nicoletti, X Wei, U Etxaniz, C D'Ercole, L Madaro… - Iscience, 2023 - cell.com
We performed scRNA-seq/snATAC-seq of skeletal muscles post sciatic nerve transection to
delineate cell type-specific patterns of gene expression/chromatin accessibility at different …