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[HTML][HTML] The SLC9A-C mammalian Na+/H+ exchanger family: molecules, mechanisms, and physiology
Na+/H+ exchangers play pivotal roles in the control of cell and tissue pH by mediating the
electroneutral exchange of Na+ and H+ across cellular membranes. They belong to an …
electroneutral exchange of Na+ and H+ across cellular membranes. They belong to an …
Evolutionary origins of eukaryotic sodium/proton exchangers
More than 200 genes annotated as Na+/H+ hydrogen exchangers (NHEs) currently reside in
bioinformation databases such as GenBank and Pfam. We performed detailed phylogenetic …
bioinformation databases such as GenBank and Pfam. We performed detailed phylogenetic …
Structural and functional analysis of the Na+/H+ exchanger
The mammalian NHE (Na+/H+ exchanger) is a ubiquitously expressed integral membrane
protein that regulates intracellular pH by removing a proton in exchange for an extracellular …
protein that regulates intracellular pH by removing a proton in exchange for an extracellular …
Regulatory binding partners and complexes of NHE3
NHE3 is the brush-border (BB) Na+/H+ exchanger of small intestine, colon, and renal
proximal tubule which is involved in large amounts of neutral Na+ absorption. NHE3 is a …
proximal tubule which is involved in large amounts of neutral Na+ absorption. NHE3 is a …
The Na+/H+ exchanger isoform 1
The Na+/H+ exchanger (NHE) isoform 1 is a ubiquitously expressed integral membrane
protein which regulates intracellular pH in mammalian cells. Nine isoforms of the Na+/H+ …
protein which regulates intracellular pH in mammalian cells. Nine isoforms of the Na+/H+ …
The Na+/H+ exchanger: a target for cardiac therapeutic intervention
The Na+/H+ exchanger (NHE) is a ubiquitous protein present in mammalian cells. In higher
eukaryotes this integral membrane protein removes one intracellular H+ for one extracellular …
eukaryotes this integral membrane protein removes one intracellular H+ for one extracellular …
A novel carbonic anhydrase II binding site regulates NHE1 activity
Carbonic anhydrase II (CAII) binds to and regulates transport by the NHE1 isoform of the
mammalian Na+/H+ exchanger. We localized and characterized the CAII binding region on …
mammalian Na+/H+ exchanger. We localized and characterized the CAII binding region on …
Na+/H+ exchanger NHE1 regulation modulates metastatic potential and epithelial-mesenchymal transition of triple-negative breast cancer cells
In triple-negative breast cancer (TNBC), the high recurrence rate, increased invasion and
aggressive metastatic formation dictate patient survival. We previously demonstrated a …
aggressive metastatic formation dictate patient survival. We previously demonstrated a …
Molecular biology of the myocardial Na+/H+ exchanger
The mammalian Na+/H+ exchanger is a pH regulatory membrane protein that uses the
sodium gradient to translocate one intracellular proton in exchange for one extracellular …
sodium gradient to translocate one intracellular proton in exchange for one extracellular …
Structural and functional characterization of transmembrane segment IV of the NHE1 isoform of the Na+/H+ exchanger
The Na+/H+ exchanger isoform 1 is a ubiquitously expressed integral membrane protein
that regulates intracellular pH in mammals. We characterized the structural and functional …
that regulates intracellular pH in mammals. We characterized the structural and functional …