p53 modulation of autophagy signaling in cancer therapies: perspectives mechanism and therapeutic targets
The key tumor suppressor protein p53, additionally known as p53, represents an attractive
target for the development and management of anti-cancer therapies. p53 has been …
target for the development and management of anti-cancer therapies. p53 has been …
Flavonoids against non-physiologic inflammation attributed to cancer initiation, development, and progression—3PM pathways
Inflammation is an essential pillar of the immune defense. On the other hand, chronic
inflammation is considered a hallmark of cancer initiation and progression. Chronic …
inflammation is considered a hallmark of cancer initiation and progression. Chronic …
Interplay between stress and cancer—a focus on inflammation
S Vignjević Petrinović, MS Milošević… - Frontiers in …, 2023 - frontiersin.org
Stress is an integral part of life. While acute responses to stress are generally regarded as
beneficial in dealing with immediate threats, chronic exposure to threatening stimuli exerts …
beneficial in dealing with immediate threats, chronic exposure to threatening stimuli exerts …
p53/NF-kB balance in SARS-CoV-2 infection: From OMICs, genomics and pharmacogenomics insights to tailored therapeutic perspectives (COVIDomics)
D Milani, L Caruso, E Zauli, AM Al Owaifeer… - Frontiers in …, 2022 - frontiersin.org
SARS-CoV-2 infection affects different organs and tissues, including the upper and lower
airways, the lung, the gut, the olfactory system and the eye, which may represent one of the …
airways, the lung, the gut, the olfactory system and the eye, which may represent one of the …
Nano-targeting vascular remodeling in cancer: recent developments and future directions
Tumor growth and progression are strictly dependent on the adequate blood supply of
oxygen and nutrients. The formation of new blood vessels and vascular networks is …
oxygen and nutrients. The formation of new blood vessels and vascular networks is …
Mutant p53 in cell-cell interactions
S Pilley, TA Rodriguez, KH Vousden - Genes & development, 2021 - genesdev.cshlp.org
Abstract p53 is an important tumor suppressor, and the complexities of p53 function in
regulating cancer cell behaviour are well established. Many cancers lose or express mutant …
regulating cancer cell behaviour are well established. Many cancers lose or express mutant …
ATF6 supports lysosomal function in tumor cells to enable ER stress-activated macroautophagy and CMA: impact on mutant TP53 expression
R Benedetti, MA Romeo, A Arena… - Autophagy, 2024 - Taylor & Francis
The inhibition of the unfolded protein response (UPR), which usually protects cancer cells
from stress, may be exploited to potentiate the cytotoxic effect of drugs inducing ER stress …
from stress, may be exploited to potentiate the cytotoxic effect of drugs inducing ER stress …
Modulation of CD4 T cell response according to tumor cytokine microenvironment
Simple Summary It is now accepted that CD4 T lymphocytes play an essential role in the anti-
tumor response. CD4 T lymphocytes can activate and regulate several aspects of innate and …
tumor response. CD4 T lymphocytes can activate and regulate several aspects of innate and …
VPA and TSA interrupt the interplay between mutp53 and HSP70, leading to CHK1 and RAD51 down-regulation and sensitizing pancreatic cancer cells to AZD2461 …
HDAC inhibitors (HDACi) represent promising anti-cancer treatments, as the acetylation of
histone and non-histone proteins is often dysregulated in cancer and contributes to cancer …
histone and non-histone proteins is often dysregulated in cancer and contributes to cancer …
[HTML][HTML] Post-Translational Modifications (PTMs) of mutp53 and Epigenetic Changes Induced by mutp53
Simple Summary Post-translational modifications (PTMs) strongly influence the stability and
function of proteins. These modifications have been reported to affect wild-type (wt) p53 as …
function of proteins. These modifications have been reported to affect wild-type (wt) p53 as …