Electroneutral cation-Cl− cotransporters compose a family of solute carriers in which cation
(Na+ or K+) movement through the plasma membrane is always accompanied by Cl− in a 1 …

This review intends to summarize the vast literature on K-Cl cotransport (COT) regulation
from a functional and genetic viewpoint. Special attention has been given to the signaling …

J. Neurochem.(2010) 115, 1123–1136. Abstract Ammonium (NH4+) is required to maintain
pathways involved in shuttling metabolic precursors between astrocytes and neurones …

Human mesial temporal lobe epilepsy (MTLE) features subregion‐specific hippocampal
neurodegeneration and reactive astrogliosis, including up‐regulation of the glial fibrillary …

Both Cs+ and NH4+ alter neuronal Cl− homeostasis, yet the mechanisms have not been
clearly elucidated. We hypothesized that these two cations altered the operation of the …

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Non‐technical summary The inhibitory neurotransmitter GABA activates two distinct
receptors of which the GABAA receptor is mainly a Cl− conducting ion channel. The proper …

The histaminergic neurons in the tuberomamillary nucleus (TMN) of the posterior
hypothalamus are involved in the control of arousal. These neurons are sensitive to …

Hyperpolarizing synaptic inhibition through GABA A and glycine receptors depends on the
presence of the neuronal cation-chloride-cotransporter protein, KCC2. Several …

Key points A polymorphism of human AE3 is associated with idiopathic generalized
epilepsy. Knockout of AE3 in mice lowers the threshold for triggering epileptic seizures. The …