Riboswitches are structured noncoding RNA domains used by many bacteria to monitor the
concentrations of target ligands and regulate gene expression accordingly. In the past 20 …

The origin story and emergence of molecular biology is muddled. The early triumphs in
bacterial genetics and the complexity of animal and plant genomes complicate an intricate …

More than 55 distinct classes of riboswitches that respond to small metabolites or elemental
ions have been experimentally validated to date. The ligands sensed by these riboswitches …

Structured noncoding RNAs (ncRNAs) contribute to many important cellular processes
involving chemical catalysis, molecular recognition and gene regulation. Few ncRNA …

Riboswitches rely on structured aptamer domains to selectively sense their target ligands
and regulate gene expression. However, some riboswitch aptamers in bacteria carry …

The aptamer portions of previously reported riboswitch classes that sense guanine, adenine,
or 2′-deoxyguanosine are formed by a highly similar three-stem junction with distinct …

Riboswitch architectures that involve the binding of a single ligand to a single RNA aptamer
domain result in ordinary dose-response curves that require approximately a 100-fold …

Riboswitches are conserved non-coding domains in bacterial mRNA with gene regulation
function that are essential for maintaining enzyme co-factor metabolism. Recently, the pnuC …

Riboswitches are metabolite-binding RNA regulators that modulate gene expression at the
levels of transcription and translation. One of the hallmarks of riboswitch regulation is that …

Riboswitches have received significant attention over the last two decades for their multiple
functionalities and great potential for applications in various fields. This article highlights and …