MarR family transcription factors: dynamic variations on a common scaffold

DK Deochand, A Grove - Critical reviews in biochemistry and …, 2017 - Taylor & Francis
Members of the multiple antibiotic resistance regulator (MarR) family of transcription factors
are critical for bacterial cells to respond to chemical signals and to convert such signals into …

Antimicrobial resistance (AMR) nanomachines—mechanisms for fluoroquinolone and glycopeptide recognition, efflux and/or deactivation

MK Phillips-Jones, SE Harding - Biophysical Reviews, 2018 - Springer
In this review, we discuss mechanisms of resistance identified in bacterial agents
Staphylococcus aureus and the enterococci towards two priority classes of antibiotics—the …

Transcriptional Regulation of icaADBC by both IcaR and TcaR in Staphylococcus epidermidis

TM Hoang, C Zhou, JK Lindgren, MR Galac… - Journal of …, 2019 - Am Soc Microbiol
ABSTRACT S. epidermidis is a primary cause of biofilm-mediated infections in humans due
to adherence to foreign bodies. A major staphylococcal biofilm accumulation molecule is …

Reciprocal regulation of Yersinia pestis biofilm formation and virulence by RovM and RovA

L Liu, H Fang, H Yang, Y Zhang, Y Han… - Open …, 2016 - royalsocietypublishing.org
RovA is known to enhance Yersinia pestis virulence by directly upregulating the psa loci.
This work presents a complex gene regulatory paradigm involving the reciprocal regulatory …

How aromatic compounds block DNA binding of HcaR catabolite regulator

Y Kim, G Joachimiak, L Bigelow, G Babnigg… - Journal of biological …, 2016 - ASBMB
Bacterial catabolism of aromatic compounds from various sources including
phenylpropanoids and flavonoids that are abundant in soil plays an important role in the …

Structural analysis of the regulatory mechanism of MarR protein Rv2887 in M. tuberculosis

YR Gao, DF Li, J Fleming, YF Zhou, Y Liu, JY Deng… - Scientific Reports, 2017 - nature.com
MarR family proteins are transcriptional regulators that control expression of bacterial
proteins involved in metabolism, virulence, stress responses and multi-drug resistance …

[HTML][HTML] Various mutations in icaR, the repressor of the icaADBC locus, occur in mucoid Staphylococcus aureus isolates recovered from the airways of people with …

B Schwartbeck, CH Rumpf, RJ Hait, T Janssen… - Microbes and …, 2024 - Elsevier
Staphylococcus aureus is one of the major pathogens isolated from the airways of people
with cystic fibrosis (pwCF). Recently, we described a mucoid S. aureus phenotype from …

Structure and function analysis of protein–nucleic acid complexes

SA Kuznetsova, TS Oretskaya - Russian Chemical Reviews, 2016 - iopscience.iop.org
The review summarizes published data on the results and achievements in the field of
structure and function analysis of protein–nucleic acid complexes by means of main physical …

Studying the recognition mechanism of TcaR and ssDNA using molecular dynamic simulations

J Fan, H Zhang, Y Mu, Q Zheng - Journal of Molecular Graphics and …, 2018 - Elsevier
The transcription regulator teicoplanin-associate locus regulator (TcaR) plays a vital role in
interfering with ssDNA replication and resisting ssDNA phage invasion. Although recent …

[PDF][PDF] Signaling Pathways Sustaining Antibiotic Resistance: Lessons From Methicillin-Resistant Staphylococcus aureus

PFS Etet, AHN Kamdje, L Vecchio, M Farahna… - Antibiotic …, 2016 - researchgate.net
The incidence of multidrug-resistant bacteria or superbugs has been increasing worldwide.
Multidrug-resistant bacteria constitute a major threat to public health as these lethal …