The GATA family of transcription factors consists of six proteins (GATA1-6) which are
involved in a variety of physiological and pathological processes. GATA1/2/3 are required …

Study of monogenic congenital heart disease (CHD) has provided entry points to gain new
understanding of heart development and the molecular pathogenesis of CHD. In this review …

Genome-wide association studies have identified 240 independent loci associated with type
2 diabetes (T2D) risk, but this knowledge has not advanced precision medicine. In contrast …

Congenital heart disease (CHD) is the most common birth defect in humans, and the
etiology of most CHD remains to be elusive. Atrial septal defect (ASD) makes up 30–40% of …

GATA4 is a particularly important cardiogenic transcription factor and serves as a potent
driver of cardiogenesis. Recent progress in the field has made it clear that histone …

Background: Pediatric Intestinal Pseudo-obstruction (PIPO) is a congenital enteric disorder
characterized by severe gastrointestinal (GI) dysmotility, without mechanical obstruction …

Congenital heart disease (CHD) is the most common birth abnormality, and more than 40%
CHD subtypes are sporadic atrial septal defect (ASD) and ventricular septal defect (VSD) …

Abstract Background The occurrence of Congenital Heart Disease (CHD) is resulted from
either genetic or environmental factors or the both. The CITED2 gene deletion or mutation is …

The septation defect is one of the main categories of congenital heart disease (CHD). They
can affect the septation of the atria leading to atrial septal defect (ASD), septation of …

CITED2 was identified as a cardiac transcription factor which is essential to the heart
development. Cited2-deficient mice showed cardiac malformations, adrenal agenesis and …