Transfer RNA (tRNA) is an adapter molecule that links a specific codon in mRNA with its
corresponding amino acid during protein synthesis. tRNAs are enzymatically modified post …

RNA modifications have been historically considered as fine-tuning chemo-structural
features of infrastructural RNAs, such as rRNAs, tRNAs, and snoRNAs. This view has …

Common diseases are often complex because they are genetically heterogeneous, with
many different genetic defects giving rise to clinically indistinguishable phenotypes. This has …

The study of eukaryotic tRNA processing has given rise to an explosion of new information
and insights in the last several years. We now have unprecedented knowledge of each step …

Transfer RNAs (tRNAs) are key for efficient and accurate protein translation. To be fully
active, tRNAs need to be heavily modified post-transcriptionally. Growing evidence indicates …

Genetic factors have an important role in the aetiology of mental retardation. However, their
contribution is often underestimated because in developed countries, severely affected …

Nm (2′-O-methylation) is one of the most common modifications in the RNA world. It has
the potential to influence the RNA molecules in multiple ways, such as structure, stability …

Intellectual disability (ID), also referred to as mental retardation (MR), is frequently the result
of genetic mutation. Where ID is present together with additional clinical symptoms or …

Abstract ALKBH1 is a 2-oxoglutarate-and Fe2+-dependent dioxygenase responsible for
multiple cellular functions. Here, we show that ALKBH1 is involved in biogenesis of 5 …

tRNA molecules are post‐transcriptionally modified by tRNA modification enzymes.
Although composed of different chemistries, more than 40 types of human tRNA …