RBG motif bridge-like lipid transport proteins: structure, functions, and open questions
The life of eukaryotic cells requires the transport of lipids between membranes, which are
separated by the aqueous environment of the cytosol. Vesicle-mediated traffic along the …
separated by the aqueous environment of the cytosol. Vesicle-mediated traffic along the …
Mechanisms of modulation of mitochondrial architecture
Mitochondrial network architecture plays a critical role in cellular physiology. Indeed,
alterations in the shape of mitochondria upon exposure to cellular stress can cause the …
alterations in the shape of mitochondria upon exposure to cellular stress can cause the …
VAP spatially stabilizes dendritic mitochondria to locally support synaptic plasticity
O Bapat, T Purimetla, S Kruessel, M Shah… - Nature …, 2024 - nature.com
Synapses are pivotal sites of plasticity and memory formation. Consequently, synapses are
energy consumption hotspots susceptible to dysfunction when their energy supplies are …
energy consumption hotspots susceptible to dysfunction when their energy supplies are …
[HTML][HTML] Piecing together the structural organisation of lipid exchange at membrane contact sites
R Khaddaj, W Kukulski - Current opinion in cell biology, 2023 - Elsevier
Membrane contact sites (MCSs) are areas of close proximity between organelles, implicated
in transport of small molecules and in organelle biogenesis. Lipid transfer proteins at MCSs …
in transport of small molecules and in organelle biogenesis. Lipid transfer proteins at MCSs …
Interplay between membranes and biomolecular condensates in the regulation of membrane-associated cellular processes
Liquid‒liquid phase separation (LLPS) has emerged as a key mechanism for organizing
cellular spaces independent of membranes. Biomolecular condensates, which assemble …
cellular spaces independent of membranes. Biomolecular condensates, which assemble …
Orchestrating vesicular and nonvesicular membrane dynamics by intrinsically disordered proteins
Compartmentalization by membranes is a common feature of eukaryotic cells and serves to
spatiotemporally confine biochemical reactions to control physiology. Membrane‐bound …
spatiotemporally confine biochemical reactions to control physiology. Membrane‐bound …
New insights into the OSBP‒VAP cycle
VAP-A is a major endoplasmic reticulum (ER) receptor that allows this organelle to engage
numerous membrane contact sites with other organelles. One highly studied example is the …
numerous membrane contact sites with other organelles. One highly studied example is the …
MIF-like domain containing protein orchestrates cellular differentiation and virulence in the fungal pathogen Magnaporthe oryzae
Macrophage migration inhibitory factor (MIF) is a pleiotropic protein with chemotactic, pro-
inflammatory, and growth-promoting activities first discovered in mammals. In parasites, MIF …
inflammatory, and growth-promoting activities first discovered in mammals. In parasites, MIF …
ER-mitochondria contacts mediate lipid radical transfer via RMDN3/PTPIP51 phosphorylation to reduce mitochondrial oxidative stress
I Shiiba, N Ito, H Oshio, Y Ishikawa, T Nagao… - Nature …, 2025 - nature.com
The proximal domains of mitochondria and the endoplasmic reticulum (ER) are linked by
tethering factors on each membrane, allowing the efficient transport of substances, including …
tethering factors on each membrane, allowing the efficient transport of substances, including …
DGARM/C10orf76/ARMH3 for Ceramide Transfer Zone at the Endoplasmic Reticulum–Distal Golgi Contacts
Phosphatidylinositol 4-monophosphate (PtdIns (4) P) is one of the key membrane
components which mark the membrane contact sites. In the mammalian Golgi complex …
components which mark the membrane contact sites. In the mammalian Golgi complex …