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The global burden of lung cancer: current status and future trends
Lung cancer is the leading cause of cancer-related death worldwide. However, lung cancer
incidence and mortality rates differ substantially across the world, reflecting varying patterns …
incidence and mortality rates differ substantially across the world, reflecting varying patterns …
Targeting KRAS in cancer
RAS family variants—most of which involve KRAS—are the most commonly occurring
hotspot mutations in human cancers and are associated with a poor prognosis. For almost …
hotspot mutations in human cancers and are associated with a poor prognosis. For almost …
Analysis and visualization of longitudinal genomic and clinical data from the AACR project GENIE biopharma collaborative in cBioPortal
International cancer registries make real-world genomic and clinical data available, but their
joint analysis remains a challenge. AACR Project GENIE, an international cancer registry …
joint analysis remains a challenge. AACR Project GENIE, an international cancer registry …
The pentose phosphate pathway in health and disease
The pentose phosphate pathway (PPP) is a glucose-oxidizing pathway that runs in parallel
to upper glycolysis to produce ribose 5-phosphate and nicotinamide adenine dinucleotide …
to upper glycolysis to produce ribose 5-phosphate and nicotinamide adenine dinucleotide …
The current state of the art and future trends in RAS-targeted cancer therapies
Despite being the most frequently altered oncogenic protein in solid tumours, KRAS has
historically been considered 'undruggable'owing to a lack of pharmacologically targetable …
historically been considered 'undruggable'owing to a lack of pharmacologically targetable …
Quantifying the expanding landscape of clinical actionability for patients with cancer
There is a continuing debate about the proportion of cancer patients that benefit from
precision oncology, attributable in part to conflicting views as to which molecular alterations …
precision oncology, attributable in part to conflicting views as to which molecular alterations …
Chemical remodeling of a cellular chaperone to target the active state of mutant KRAS
CJ Schulze, KJ Seamon, Y Zhao, YC Yang, J Cregg… - Science, 2023 - science.org
The discovery of small-molecule inhibitors requires suitable binding pockets on protein
surfaces. Proteins that lack this feature are considered undruggable and require innovative …
surfaces. Proteins that lack this feature are considered undruggable and require innovative …
Therapeutic landscape and future direction of metastatic colorectal cancer
H Bando, A Ohtsu, T Yoshino - Nature Reviews Gastroenterology & …, 2023 - nature.com
In the era of targeted therapy based on genomic alterations, the treatment strategy for
metastatic colorectal cancer (mCRC) has been changing. Before systemic treatment …
metastatic colorectal cancer (mCRC) has been changing. Before systemic treatment …
Harnessing multimodal data integration to advance precision oncology
Advances in quantitative biomarker development have accelerated new forms of data-driven
insights for patients with cancer. However, most approaches are limited to a single mode of …
insights for patients with cancer. However, most approaches are limited to a single mode of …
[HTML][HTML] Role of FGFR3 in bladder cancer: Treatment landscape and future challenges
Bladder cancer is a heterogeneous malignancy and is responsible for approximately 3.2%
of new diagnoses of cancer per year (Sung et al., 2021). Fibroblast Growth Factor Receptors …
of new diagnoses of cancer per year (Sung et al., 2021). Fibroblast Growth Factor Receptors …