Half a century of amyloids: past, present and future
Amyloid diseases are global epidemics with profound health, social and economic
implications and yet remain without a cure. This dire situation calls for research into the …
implications and yet remain without a cure. This dire situation calls for research into the …
Metallo-β-lactamases in the age of multidrug resistance: from structure and mechanism to evolution, dissemination, and inhibitor design
Antimicrobial resistance is one of the major problems in current practical medicine. The
spread of genes coding for resistance determinants among bacteria challenges the use of …
spread of genes coding for resistance determinants among bacteria challenges the use of …
Multi-pass, single-molecule nanopore reading of long protein strands
The ability to sequence single protein molecules in their native, full-length form would
enable a more comprehensive understanding of proteomic diversity. Current technologies …
enable a more comprehensive understanding of proteomic diversity. Current technologies …
From squiggle to basepair: computational approaches for improving nanopore sequencing read accuracy
Nanopore sequencing is a rapidly maturing technology delivering long reads in real time on
a portable instrument at low cost. Not surprisingly, the community has rapidly taken up this …
a portable instrument at low cost. Not surprisingly, the community has rapidly taken up this …
UroPathogenic Escherichia coli (UPEC) Infections: Virulence Factors, Bladder Responses, Antibiotic, and Non-antibiotic Antimicrobial Strategies
Urinary tract infections (UTIs) are one of the most common pathological conditions in both
community and hospital settings. It has been estimated that about 150 million people …
community and hospital settings. It has been estimated that about 150 million people …
Recent innovations in bacterial infection detection and treatment
C Deusenbery, Y Wang, A Shukla - ACS Infectious Diseases, 2021 - ACS Publications
Bacterial infections are a major threat to human health, exacerbated by increasing antibiotic
resistance. These infections can result in tremendous morbidity and mortality, emphasizing …
resistance. These infections can result in tremendous morbidity and mortality, emphasizing …
Nanopore sequencing: Review of potential applications in functional genomics
Molecular biology has been led by various measurement technologies, and increased
throughput has developed omics analysis. The development of massively parallel …
throughput has developed omics analysis. The development of massively parallel …
Three decades of nanopore sequencing
A long-held goal in sequencing has been to use a voltage-biased nanoscale pore in a
membrane to measure the passage of a linear, single-stranded (ss) DNA or RNA molecule …
membrane to measure the passage of a linear, single-stranded (ss) DNA or RNA molecule …
DNA methylation-calling tools for Oxford Nanopore sequencing: a survey and human epigenome-wide evaluation
Background Nanopore long-read sequencing technology greatly expands the capacity of
long-range, single-molecule DNA-modification detection. A growing number of analytical …
long-range, single-molecule DNA-modification detection. A growing number of analytical …
Secretion systems in Gram-negative bacteria: structural and mechanistic insights
Bacteria have evolved a remarkable array of sophisticated nanomachines to export various
virulence factors across the bacterial cell envelope. In recent years, considerable progress …
virulence factors across the bacterial cell envelope. In recent years, considerable progress …