Therapeutic targets and biomarkers of tumor immunotherapy: response versus non-response

DR Wang, XL Wu, YL Sun - Signal transduction and targeted therapy, 2022 - nature.com
Cancers are highly complex diseases that are characterized by not only the overgrowth of
malignant cells but also an altered immune response. The inhibition and reprogramming of …

Revolutionization in cancer therapeutics via targeting major immune checkpoints PD-1, PD-L1 and CTLA-4

P Pandey, F Khan, HA Qari, TK Upadhyay… - Pharmaceuticals, 2022 - mdpi.com
Numerous research reports have witnessed dramatic advancements in cancer therapeutic
approaches through immunotherapy. Blocking immunological checkpoint pathways …

Therapeutic advances in non‐small cell lung cancer: Focus on clinical development of targeted therapy and immunotherapy

Y Cheng, T Zhang, Q Xu - MedComm, 2021 - Wiley Online Library
Lung cancer still contributes to nearly one‐quarter cancer‐related deaths in the past
decades, despite the rapid development of targeted therapy and immunotherapy in non …

[HTML][HTML] Evolving strategies and application of proteins and peptide therapeutics in cancer treatment

AG Mukherjee, UR Wanjari, AV Gopalakrishnan… - Biomedicine & …, 2023 - Elsevier
Several proteins and peptides have therapeutic potential and can be used for cancer
therapy. By binding to cell surface receptors and other indicators uniquely linked with or …

[HTML][HTML] Immune checkpoint inhibitors in non-small cell lung cancer: From current perspectives to future treatments—A systematic review

A Olivares-Hernández, EG Del Portillo… - Annals of …, 2023 - ncbi.nlm.nih.gov
Background The introduction of immunotherapy in the treatment of non-small cell lung
cancer (NSCLC) has resulted in a radical change in patients' treatment responses and …

NSCLC: from tumorigenesis, immune checkpoint misuse to current and future targeted therapy

L Raskova Kafkova, JM Mierzwicka… - Frontiers in …, 2024 - frontiersin.org
Non-small cell lung cancer (NSCLC) is largely promoted by a multistep tumorigenesis
process involving various genetic and epigenetic alterations, which essentially contribute to …

Emerging therapeutic strategies for enhancing sensitivity and countering resistance to programmed cell death protein 1 or programmed death‐ligand 1 inhibitors in …

LC Villaruz, GR Blumenschein Jr, GA Otterson… - Cancer, 2023 - Wiley Online Library
The availability of agents targeting the programmed cell death protein 1 (PD‐1)/programmed
death‐ligand 1 (PD‐L1) immune checkpoint has transformed treatment of advanced and/or …

Crosstalk between cGAS-STING pathway and autophagy in cancer immunity

Q Lu, Y Chen, J Li, F Zhu, Z Zheng - Frontiers in Immunology, 2023 - frontiersin.org
The cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway is
critical in cancer immunity. Autophagy is a highly conserved process that is responsible for …

CD33 expression on peripheral blood monocytes predicts efficacy of anti-PD-1 immunotherapy against non-small cell lung cancer

C Olingy, A Alimadadi, DJ Araujo, D Barry… - Frontiers in …, 2022 - frontiersin.org
Non-small cell lung carcinoma (NSCLC) is the leading cause of cancer-related deaths
globally. Immune checkpoint blockade (ICB) has transformed cancer medicine, with anti …

Systems biology strategy and experimental validation to uncover the pharmacological mechanism of **huang Pill in treating non-small cell lung cancer

Z Zhuang, D Huang, ZR Sheng, ZJ Ye, H Jiang, Y Yuan… - Phytomedicine, 2023 - Elsevier
Background Non-small cell lung cancer (NSCLC) accounts for almost 85% of lung cancer-
related deaths worldwide. **huang Pill (XHP) is a representative anticancer Chinese …