Cancer is caused by genetic alterations that affect cellular fitness, and multicellular
organisms have evolved mechanisms to suppress cancer such as cell cycle checkpoints …

The rodents of hystricomorpha and sciuromorpha suborders exhibit remarkably lower
incidence of cancer. The underlying genetic basis remains obscure. We report a convergent …

Deletions of chromosome 1p36 are common in malignancies; however, there is limited
information regarding the biological and prognostic implications of 1p36 in cancer. Steroid …

Cancer-related genes have evolved specific genetic and genomic features to favor tumor
suppression. Previously we reported that tumor suppressor genes (TSGs) acquired high …

Mutations in proto-oncogenes (ONGO) and the loss of regulatory function of tumor
suppression genes (TSG) are the common underlying mechanism for uncontrolled tumor …

Cancer-related genes are under intense evolutionary pressure. In this study, we conjecture
that X-linked tumor suppressor genes (TSG) are not protected by the Knudson's two-hit …

Tumor suppressor genes (TSGs) exhibit distinct evolutionary features. We speculated that
TSG promoters could have evolved specific features that facilitate their tumor-suppressing …

Background Cancer-related genes are under intense evolutionary pressure. We conjectured
that gene size is an important determinant of amplification propensity for oncogenes and …

C1ORF112 was first identified from bioinformatic searches for novel genes associated with
aging; strong correlation (co-expression) with genes of the Fanconi anaemia (FA) pathway …

Genomes evolve by acquisition, deletion, substitution, amplification, and rearrangement of
genetic material (Oliverio & Katz, 2014). These changes in genomic sequences occur due to …