Lipopolysaccharide (LPS) is a crucial constituent of the outer membrane of most Gram-
negative bacteria, playing a fundamental role in the protection of bacteria from …

The cell envelope is the first line of defense between a bacterium and the world-at-large.
Often, the initial steps that determine the outcome of chemical warfare, bacteriophage …

P. aeruginosa is classified as a priority one pathogen by the World Health Organisation, and
new drugs are urgently needed, due to the emergence of multidrug-resistant (MDR) strains …

The defining feature of the Gram-negative cell envelope is the presence of two cellular
membranes, with the specialized glycolipid lipopolysaccharide (LPS) exclusively found on …

Gram-negative bacteria have a double-membrane cellular envelope that enables them to
colonize harsh environments and prevents the entry of many clinically available antibiotics …

There is an urgent need for new antibiotics against Gram-negative pathogens that are
resistant to carbapenem and third-generation cephalosporins, against which antibiotics of …

ABSTRACT The World Health Organization (WHO) has warned that our current arsenal of
antibiotics is not innovative enough to face impending infectious diseases, especially those …

Determining the chemical composition of biological materials is paramount to the study of
natural phenomena. Here, we describe the composition of model gram-negative outer …

This review covers some of the recent progress in the field of peptide antibiotics with a focus
on compounds with novel or established mode of action and with demonstrated efficacy in …

The global increase in multi-drug-resistant bacteria is severely impacting our ability to
effectively treat common infections. For Gram-negative bacteria, their intrinsic and acquired …