Serial crystallography, born from groundbreaking experiments at the Linac Coherent Light
Source in 2009, has evolved into a pivotal technique in structural biology. Initially pioneered …

Covalent fragment approaches combine advantages of covalent binders and fragment-
based drug discovery (FBDD) for target identification and validation. Although early …

Protein function hinges on small shifts of three-dimensional structure. Elevating temperature
or pressure may provide experimentally accessible insights into such shifts, but the effects of …

In their folded state, biomolecules exchange between multiple conformational states that are
crucial for their function. Traditional structural biology methods, such as X-ray …

The ubiquitously expressed protein tyrosine phosphatase SHP2 is required for signaling
downstream of receptor tyrosine kinases (RTKs) and plays a role in regulating many cellular …

Droplet injection strategies are a promising tool to reduce the large amount of sample
consumed in serial femtosecond crystallography (SFX) measurements at X-ray free electron …

The protein-ligand binding frequently occurs in living organisms and plays a crucial role in
the execution of the functions of proteins and drugs. It is also an indispensable part of drug …

Understanding enzyme catalysis as connected to protein motions is a major challenge.
Here, based on temperature kinetic studies combined with isotope effect measurements, we …

In their folded state, biomolecules exchange between multiple conformational states that are
crucial for their function. Traditional structural biology methods, such as X-ray …

Protein tyrosine phosphatase 1B (PTP1B) plays important roles in cellular homeostasis and
is a highly validated therapeutic target for multiple human ailments, including diabetes …