Oxidative stress and the pathophysiology and symptom profile of schizophrenia spectrum disorders

AJ Murray, JC Rogers, MZUH Katshu, PF Liddle… - Frontiers in …, 2021 - frontiersin.org
Schizophrenia is associated with increased levels of oxidative stress, as reflected by an
increase in the concentrations of damaging reactive species and a reduction in anti-oxidant …

Anti-inflammatory effects of 2nd generation antipsychotics in patients with schizophrenia: A systematic review and meta-analysis

SR Patlola, G Donohoe, DP McKernan - Journal of Psychiatric Research, 2023 - Elsevier
Background Schizophrenia is a major psychiatric disorder with unknown aetiology. Recent
evidence suggests a potential role for cytokines in its pathophysiology and that antipsychotic …

Blood–brain barrier and intestinal epithelial barrier alterations in autism spectrum disorders

M Fiorentino, A Sapone, S Senger, SS Camhi… - Molecular autism, 2016 - Springer
Background Autism spectrum disorders (ASD) are complex conditions whose pathogenesis
may be attributed to gene–environment interactions. There are no definitive mechanisms …

Neuropharmacological effect of risperidone: From chemistry to medicine

AA Bhat, G Gupta, O Afzal, I Kazmi, FA Al-Abbasi… - Chemico-biological …, 2023 - Elsevier
As the second-oldest atypical antipsychotic, risperidone has a long history of off-label usage
for treating behavioural and psychological signs and symptoms of dementia (BPSD), such …

Prevalence and clinical characteristics of serum neuronal cell surface antibodies in first-episode psychosis: a case-control study

BR Lennox, EC Palmer-Cooper, T Pollak… - The Lancet …, 2017 - thelancet.com
Background Psychosis is a common presenting feature in antibody-mediated encephalitis,
for which prompt recognition and treatment usually leads to remission. We aimed to …

Inflammation in schizophrenia: a question of balance

JC Leza, B García-Bueno, M Bioque, C Arango… - Neuroscience & …, 2015 - Elsevier
In the past decade, there has been renewed interest in immune/inflammatory changes and
their associated oxidative/nitrosative consequences as key pathophysiological mechanisms …

Minocycline and antipsychotics inhibit inflammatory responses in BV-2 microglia activated by LPS via regulating the MAPKs/JAK-STAT signaling pathway

Y Long, Y Wang, Y Shen, J Huang, Y Li, R Wu, J Zhao - BMC psychiatry, 2023 - Springer
Background Abnormal activation of microglia is involved in the pathogenesis of
schizophrenia. Minocycline and antipsychotics have been reported to be effective in …

Immune abnormalities in autism spectrum disorder—could they hold promise for causative treatment?

D Gładysz, A Krzywdzińska, KK Hozyasz - Molecular neurobiology, 2018 - Springer
Autism spectrum disorders (ASD) are characterized by impairments in language and
communication development, social behavior, and the occurrence of stereotypic patterns of …

Antioxidant properties of second-generation antipsychotics: Focus on microglia

G Caruso, M Grasso, A Fidilio, F Tascedda, F Drago… - Pharmaceuticals, 2020 - mdpi.com
Recent studies suggest a primary role of oxidative stress in an early phase of the
pathogenesis of schizophrenia and a strong neurobiological link has been found between …

Effects of risperidone on cytokine profile in drug-naïve first-episode psychosis

C Noto, VK Ota, ES Gouvea, LB Rizzo… - International Journal …, 2015 - academic.oup.com
Background: There is robust evidence that schizophrenia is characterized by immune-
inflammatory abnormalities, including variations on cytokine levels. The results of previous …