Clinical studies have demonstrated that a single sub-anesthetic dose of the dissociative
anesthetic ketamine induces rapid and sustained antidepressant actions. Although this …

Altered synaptic structure and function is a major hallmark of fragile X syndrome (FXS),
autism spectrum disorders (ASDs), and other intellectual disabilities (IDs), which are …

The neuronal gene Arc is essential for long-lasting information storage in the mammalian
brain, mediates various forms of synaptic plasticity, and has been implicated in …

In the brain, neuronal gene expression is dynamically changed in response to neuronal
activity. In particular, the expression of immediate-early genes (IEGs) such as egr-1, c-fos …

Clinical studies consistently demonstrate that a single sub-psychomimetic dose of ketamine,
an ionotropic glutamatergic NMDAR (N-methyl-D-aspartate receptor) antagonist, produces …

Brain-derived neurotrophic factor (BDNF) is an important regulator of synaptic transmission
and long-term potentiation (LTP) in the hippocampus and in other brain regions, playing a …

Synapses between neurons are malleable biochemical structures, strengthening and
diminishing over time dependent on the type of information they receive. This phenomenon …

Soluble amyloid-β oligomers (Aβo) trigger Alzheimer's disease (AD) pathophysiology and
bind with high affinity to cellular prion protein (PrP C). At the postsynaptic density (PSD) …

The neurotrophin brain-derived neurotrophic factor (BDNF) has emerged as a major
regulator of activity-dependent plasticity at excitatory synapses in the mammalian central …

Neuronal activity induces the post-translational modification of synaptic molecules, promotes
localized protein synthesis within dendrites and activates gene transcription, thereby …