Intervertebral disc (IVD) degeneration is a major cause of low back pain, a prevalent and
chronic condition that has a striking effect on quality of life. Currently, no approved …

Degeneration of the intervertebral disc (IVD) is a normal part of aging. Due to the spine's
declining function and the development of pain, it may affect one's physical health, mental …

Intervertebral disc (IVD) degeneration can cause chronic lower back pain (LBP), leading to
disability. Despite significant advances in the treatment of discogenic LBP, the limitations of …

Low back pain (LBP) can significantly reduce the quality of life of patients, and has a
considerable economic and social impact worldwide. It is commonly associated with disc …

In recent years, various quantitative and functional magnetic resonance imaging (MRI)
sequences have been developed and used in clinical practice for the diagnosis of patients …

Intervertebral disc (IVD) degeneration is a major risk factor of low back pain. It is defined by a
progressive loss of the IVD structure and functionality, leading to severe impairments with …

Extracellular vesicles (EVs) are lipid membrane particles carrying proteins, lipids, DNA, and
various types of RNA that are involved in intercellular communication. EVs derived from …

Intervertebral disc degeneration (IVDD) is a prevalent cause of low back pain. IVDD is
characterized by abnormal expression of extracellular matrix components such as collagen …

Intervertebral disc (IVD) degeneration is a major cause of low back pain and represents a
massive socioeconomic burden. Current conservative and surgical treatments fail to restore …

Background Intervertebral disc (IVD) degeneration is one of the primary causes of low back
pain (LBP) and despite a prominent prevalence, present treatment options remain …