Design, Synthesis, and Biological Activity Evaluation of Novel AZT and Adenosine‐Derived 1, 2, 3‐Triazoles
CuSO4/hydrazine hydrate was used as a catalyst system for copper (I)‐catalyzed alkyne‐
azide cycloaddition (CuAAC) of AZT and 5′‐azido adenosine with terminal alkynes to give …
azide cycloaddition (CuAAC) of AZT and 5′‐azido adenosine with terminal alkynes to give …
Ethyl gallate ameliorates diabetes-induced Alzheimer's disease-like phenotype in rats via activation of α7 nicotinic receptors and mitigation of oxidative stress
Cognitive decline, an important comorbidity of type 2 diabetes (T2D), is attributed to
oxidative stress and impaired cholinergic signaling in the brain. The α7 nicotinic …
oxidative stress and impaired cholinergic signaling in the brain. The α7 nicotinic …
Cotton flower metabolites inhibit SARS‐CoV‐2 main protease
Y Zhang, W Li, Y Hu, T Ding, MM Zafar, X Jia… - FEBS Open …, 2022 - Wiley Online Library
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has been spreading
globally for over 2 years, causing serious contagious disease and incalculable damage. The …
globally for over 2 years, causing serious contagious disease and incalculable damage. The …
Molecular structure, antioxidant potential, and pharmacokinetic properties of plant flavonoid blumeatin and investigating its inhibition mechanism on xanthine oxidase …
Hyperuricemia, which usually results in metabolic syndrome symptoms, is increasing rapidly
all over the world and becoming a global public health issue. Xanthine oxidase (XO) is …
all over the world and becoming a global public health issue. Xanthine oxidase (XO) is …
Quinoline‐Dihydropyrimidin‐2(1H)‐one Hybrids: Synthesis, Biological Activity, and Mechanistic Studies
A novel class of quinoline‐dihydropyrimidin‐2 (1H)‐one (DHPM) hybrids was synthesized
and in vitro antiplasmodial activity was evaluated against chloroquine sensitive (D10) and …
and in vitro antiplasmodial activity was evaluated against chloroquine sensitive (D10) and …
Anti-inflammatory and chondroprotective effects induced by phenolic compounds from onion waste extracts in ATDC-5 chondrogenic cell line
Osteoarthritis is a prevalent degenerative condition that is closely related to the destruction
and inflammation of cartilage. The high prevalence of this pathology exhorts researchers to …
and inflammation of cartilage. The high prevalence of this pathology exhorts researchers to …
Potential Anti-SARS-CoV-2 Molecular Strategies
C Vicidomini, GN Roviello - Molecules, 2023 - mdpi.com
Finding effective antiviral molecular strategies was a main concern in the scientific
community when the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …
community when the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …
Dynamic study of small toxic hydrophobic proteins PepA1 and PepG1 of Staphylococcus aureus
Toxin-antitoxin (TA) systems are small genetic elements which encode toxin proteins that
interfere with vital cellular functions. PepA1 and PepG1 toxin proteins, known also as SprA1 …
interfere with vital cellular functions. PepA1 and PepG1 toxin proteins, known also as SprA1 …
Boar sperm cryopreservation improvement using semen extender modification by dextran and pentaisomaltose
O Simonik, F Bubenickova, L Tumova, M Frolikova… - Animals, 2022 - mdpi.com
Simple Summary Cryopreservation of sperm is an important process used in livestock
breeding. It is used to facilitate artificial insemination and helps to maintain genetic diversity …
breeding. It is used to facilitate artificial insemination and helps to maintain genetic diversity …
Specific inhibition of vanZ-mediated resistance to lipoglycopeptide antibiotics
Teicoplanin is a natural lipoglycopeptide antibiotic with a similar activity spectrum as
vancomycin; however, it has with the added benefit to the patient of low cytotoxicity. Both …
vancomycin; however, it has with the added benefit to the patient of low cytotoxicity. Both …