von Willebrand factor, Jedi knight of the bloodstream
TA Springer - Blood, The Journal of the American Society of …, 2014 - ashpublications.org
When blood vessels are cut, the forces in the bloodstream increase and change character.
The dark side of these forces causes hemorrhage and death. However, von Willebrand …
The dark side of these forces causes hemorrhage and death. However, von Willebrand …
Role of fluid shear stress in regulating VWF structure, function and related blood disorders
S Gogia, S Neelamegham - Biorheology, 2015 - content.iospress.com
Von Willebrand factor (VWF) is the largest glycoprotein in blood. It plays a crucial role in
primary hemostasis via its binding interaction with platelet and endothelial cell surface …
primary hemostasis via its binding interaction with platelet and endothelial cell surface …
Force interacts with macromolecular structure in activation of TGF-β
Integrins are adhesion receptors that transmit force across the plasma membrane between
extracellular ligands and the actin cytoskeleton. In activation of the transforming growth …
extracellular ligands and the actin cytoskeleton. In activation of the transforming growth …
Conformational activation of ADAMTS13
A disintegrin and metalloprotease with thrombospondin motifs 13 (ADAMTS13) is a
metalloprotease that regulates von Willebrand factor (VWF) function. ADAMTS13-mediated …
metalloprotease that regulates von Willebrand factor (VWF) function. ADAMTS13-mediated …
Biology and physics of von Willebrand factor concatamers
TA Springer - Journal of thrombosis and haemostasis, 2011 - Wiley Online Library
Structural specialisations enable von Willebrand factor (VWF) to assemble during
biosynthesis into helical tubules in Weibel‐Palade bodies (WPB). Specialisations include a …
biosynthesis into helical tubules in Weibel‐Palade bodies (WPB). Specialisations include a …
Multiplexed protein force spectroscopy reveals equilibrium protein folding dynamics and the low-force response of von Willebrand factor
A Löf, PU Walker, SM Sedlak… - Proceedings of the …, 2019 - National Acad Sciences
Single-molecule force spectroscopy has provided unprecedented insights into protein
folding, force regulation, and function. So far, the field has relied primarily on atomic force …
folding, force regulation, and function. So far, the field has relied primarily on atomic force …
Von Willebrand factor: form for function
A Yee, CA Kretz - Seminars in thrombosis and hemostasis, 2014 - thieme-connect.com
The mechanisms by which von Willebrand factor (VWF) achieves hemostasis lie in its
structure. Whereas low-molecular-weight forms have diminished hemostatic potential …
structure. Whereas low-molecular-weight forms have diminished hemostatic potential …
Force-sensitive autoinhibition of the von Willebrand factor is mediated by interdomain interactions
Von Willebrand factor (VWF) plays a central role in hemostasis. Triggered by shear-stress, it
adheres to platelets at sites of vascular injury. Inactivation of VWF has been associated to …
adheres to platelets at sites of vascular injury. Inactivation of VWF has been associated to …
ADAMTS13: origins, applications, and prospects
WE Plautz, JS Raval, MR Dyer, MA Rollins‐Raval… - …, 2018 - Wiley Online Library
ADAMTS13 is an enzyme that acts by cleaving prothrombotic von Willebrand factor (VWF)
multimers from the vasculature in a highly regulated manner. In pathologic states such as …
multimers from the vasculature in a highly regulated manner. In pathologic states such as …
Helical self-assembly of a mucin segment suggests an evolutionary origin for von Willebrand factor tubules
The glycoprotein von Willebrand factor (VWF) contributes to hemostasis by stanching
injuries in blood vessel walls. A distinctive feature of VWF is its assembly into long, helical …
injuries in blood vessel walls. A distinctive feature of VWF is its assembly into long, helical …