The COMPASS family of histone H3K4 methylases: mechanisms of regulation in development and disease pathogenesis
A Shilatifard - Annual review of biochemistry, 2012 - annualreviews.org
The Saccharomyces cerevisiae Set1/COMPASS was the first histone H3 lysine 4 (H3K4)
methylase identified over 10 years ago. Since then, it has been demonstrated that …
methylase identified over 10 years ago. Since then, it has been demonstrated that …
TGF-β signalling and its role in cancer progression and metastasis
Y Drabsch, P Ten Dijke - Cancer and Metastasis Reviews, 2012 - Springer
The transforming growth factor-β (TGF-β) system signals via protein kinase receptors and
SMAD mediators to regulate a large number of biological processes. Alterations of the TGF …
SMAD mediators to regulate a large number of biological processes. Alterations of the TGF …
Enhancer-associated H3K4 monomethylation by Trithorax-related, the Drosophila homolog of mammalian Mll3/Mll4
Monomethylation of histone H3 on Lys 4 (H3K4me1) and acetylation of histone H3 on Lys
27 (H3K27ac) are histone modifications that are highly enriched over the body of actively …
27 (H3K27ac) are histone modifications that are highly enriched over the body of actively …
[HTML][HTML] Genetic and epigenetic biomarkers for diagnosis, prognosis and treatment of colorectal cancer
F Coppedè, A Lopomo, R Spisni… - World journal of …, 2014 - ncbi.nlm.nih.gov
Colorectal cancer (CRC) is one of the most common cancer worldwide and results from the
accumulation of mutations and epimutations in colonic mucosa cells ultimately leading to …
accumulation of mutations and epimutations in colonic mucosa cells ultimately leading to …
[HTML][HTML] Genetic and epigenetic alterations of colorectal cancer
SN Hong - Intestinal research, 2018 - synapse.koreamed.org
Colorectal cancer (CRC) arise from multi-step carcinogenesis due to genetic mutations and
epigenetic modifications of human genome. Genetic mutations and epigenetic modifications …
epigenetic modifications of human genome. Genetic mutations and epigenetic modifications …
[HTML][HTML] Colorectal cancer disparity in African Americans: risk factors and carcinogenic mechanisms
African Americans have the highest incidence and mortality rates of colorectal cancer (CRC)
of any ethnic group in the United States. Although some of these disparities can be …
of any ethnic group in the United States. Although some of these disparities can be …
MLL3/MLL4/COMPASS family on epigenetic regulation of enhancer function and cancer
During development, precise spatiotemporal patterns of gene expression are coordinately
controlled by cis-regulatory modules known as enhancers. Their crucial role in development …
controlled by cis-regulatory modules known as enhancers. Their crucial role in development …
Enhancer malfunction in cancer
Why certain point mutations in a general transcription factor are associated with specific
forms of cancer has been a major question in cancer biology. Enhancers are DNA regulatory …
forms of cancer has been a major question in cancer biology. Enhancers are DNA regulatory …
The COMPASS family of H3K4 methylases in Drosophila
M Mohan, HM Herz, ER Smith, Y Zhang… - … and cellular biology, 2011 - Am Soc Microbiol
Methylation of histone H3 lysine 4 (H3K4) in Saccharomyces cerevisiae is implemented by
Set1/COMPASS, which was originally purified based on the similarity of yeast Set1 to human …
Set1/COMPASS, which was originally purified based on the similarity of yeast Set1 to human …
Comprehensive analysis of copy number aberrations in microsatellite stable colon cancer in view of stromal component
MH Alonso, S Aussó, A Lopez-Doriga… - British journal of …, 2017 - nature.com
Background: Somatic copy number aberrations (CNAs) are common acquired changes in
cancer cells having an important role in the progression of colon cancer (colorectal cancer …
cancer cells having an important role in the progression of colon cancer (colorectal cancer …