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Cytokine storm and leukocyte changes in mild versus severe SARS-CoV-2 infection: Review of 3939 COVID-19 patients in China and emerging pathogenesis and …
Clinical evidence indicates that the fatal outcome observed with severe acute respiratory
syndrome-coronavirus-2 infection often results from alveolar injury that impedes airway …
syndrome-coronavirus-2 infection often results from alveolar injury that impedes airway …
Hemagglutinin stability and its impact on influenza A virus infectivity, pathogenicity, and transmissibility in avians, mice, swine, seals, ferrets, and humans
CJ Russell - Viruses, 2021 - mdpi.com
Genetically diverse influenza A viruses (IAVs) circulate in wild aquatic birds. From this
reservoir, IAVs sporadically cause outbreaks, epidemics, and pandemics in wild and …
reservoir, IAVs sporadically cause outbreaks, epidemics, and pandemics in wild and …
Deep mutational scanning of H5 hemagglutinin to inform influenza virus surveillance
H5 influenza is considered a potential pandemic threat. Recently, H5 viruses belonging to
clade 2.3. 4.4 b have caused large outbreaks in avian and multiple nonhuman mammalian …
clade 2.3. 4.4 b have caused large outbreaks in avian and multiple nonhuman mammalian …
[HTML][HTML] Hemagglutinin stability as a key determinant of influenza A virus transmission via air
II Tosheva, KS Saygan, SMA Mijnhardt… - Current Opinion in …, 2023 - Elsevier
To cause pandemics, zoonotic respiratory viruses need to adapt to replication in and spread
between humans, either via (indirect or direct) contact or through the air via droplets and …
between humans, either via (indirect or direct) contact or through the air via droplets and …
Cigarette smoke affects dendritic cell populations, epithelial barrier function, and the immune response to viral infection with H1N1
Smokers with apparently “healthy” lungs suffer from more severe and frequent viral
respiratory infections, but the mechanisms underlying this observation are still unclear …
respiratory infections, but the mechanisms underlying this observation are still unclear …
Hemagglutinin destabilization in H3N2 vaccine reference viruses skews antigenicity and prevents airborne transmission in ferrets
During influenza virus entry, the hemagglutinin (HA) protein binds receptors and causes
membrane fusion after endosomal acid activation. To improve vaccine efficiency and …
membrane fusion after endosomal acid activation. To improve vaccine efficiency and …
Dampening of ISGylation of RIG-I by ADAP regulates type I interferon response of macrophages to RNA virus infection
Y Wang, H Feng, X Li, Y Ruan, Y Guo, X Cui… - Plos …, 2024 - journals.plos.org
While macrophage is one of the major type I interferon (IFN-I) producers in multiple tissues
during viral infections, it also serves as an important target cell for many RNA viruses …
during viral infections, it also serves as an important target cell for many RNA viruses …
Relationship between hemagglutinin stability and influenza virus persistence after exposure to low pH or supraphysiological heating
The hemagglutinin (HA) surface glycoprotein is triggered by endosomal low pH to cause
membrane fusion during influenza A virus (IAV) entry yet must remain sufficiently stable to …
membrane fusion during influenza A virus (IAV) entry yet must remain sufficiently stable to …
Hemagglutinin glycosylation pattern-specific effects: implications for the fitness of H9. 4.2. 5-branched H9N2 avian influenza viruses
Y Sun, Y Zhu, P Zhang, S Sheng, Z Guan… - Emerging Microbes & …, 2024 - Taylor & Francis
ABSTRACT Since 2007, h9. 4.2. 5 has emerged as the most predominant branch of H9N2
avian influenza viruses (AIVs) that affects the majority of the global poultry population. The …
avian influenza viruses (AIVs) that affects the majority of the global poultry population. The …
HA stabilization promotes replication and transmission of swine H1N1 gamma influenza viruses in ferrets
M Hu, G Yang, J DeBeauchamp, JC Crumpton, H Kim… - Elife, 2020 - elifesciences.org
Pandemic influenza A viruses can emerge from swine, an intermediate host that supports
adaptation of human-preferred receptor-binding specificity by the hemagglutinin (HA) …
adaptation of human-preferred receptor-binding specificity by the hemagglutinin (HA) …