Protein cages: from fundamentals to advanced applications
Proteins that self-assemble into polyhedral shell-like structures are useful molecular
containers both in nature and in the laboratory. Here we review efforts to repurpose diverse …
containers both in nature and in the laboratory. Here we review efforts to repurpose diverse …
[HTML][HTML] Formulation, stabilisation and encapsulation of bacteriophage for phage therapy
Against a backdrop of global antibiotic resistance and increasing awareness of the
importance of the human microbiota, there has been resurgent interest in the potential use of …
importance of the human microbiota, there has been resurgent interest in the potential use of …
Phage therapy: What factors shape phage pharmacokinetics and bioavailability? Systematic and critical review
K Dąbrowska - Medicinal research reviews, 2019 - Wiley Online Library
Bacteriophages are not forgotten viruses anymore: scientists and practitioners seek to
understand phage pharmacokinetics in animals and humans, investigating bacteriophages …
understand phage pharmacokinetics in animals and humans, investigating bacteriophages …
Engineered CRISPR-Cas systems for the detection and control of antibiotic-resistant infections
Y Wu, D Battalapalli, MJ Hakeem, V Selamneni… - Journal of …, 2021 - Springer
Antibiotic resistance is spreading rapidly around the world and seriously impeding efforts to
control microbial infections. Although nucleic acid testing is widely deployed for the …
control microbial infections. Although nucleic acid testing is widely deployed for the …
Gram-positive bacterial extracellular vesicles and their impact on health and disease
During recent years it has become increasingly clear that the release of extracellular
vesicles (EVs) is a feature inherent to all cellular life forms. These lipid bilayer-enclosed …
vesicles (EVs) is a feature inherent to all cellular life forms. These lipid bilayer-enclosed …
Drug delivery strategies for antibiofilm therapy
Although new antibiofilm agents have been developed to prevent and eliminate pathogenic
biofilms, their widespread clinical use is hindered by poor biocompatibility and …
biofilms, their widespread clinical use is hindered by poor biocompatibility and …
[HTML][HTML] Recent advances in bacteriophage-based therapeutics: Insight into the post-antibiotic era
H Ling, X Lou, Q Luo, Z He, M Sun, J Sun - Acta Pharmaceutica Sinica B, 2022 - Elsevier
Antibiotic resistance is one of the biggest threats to global health, as it can make the
treatment of bacterial infections in humans difficult owing to their high incidence rate …
treatment of bacterial infections in humans difficult owing to their high incidence rate …
Pharmacologically aware phage therapy: pharmacodynamic and pharmacokinetic obstacles to phage antibacterial action in animal and human bodies
K Dąbrowska, ST Abedon - Microbiology and Molecular Biology …, 2019 - Am Soc Microbiol
The use of viruses infecting bacteria (bacteriophages or phages) to treat bacterial infections
has been ongoing clinically for approximately 100 years. Despite that long history, the …
has been ongoing clinically for approximately 100 years. Despite that long history, the …
Phage therapy efficacy: a review of the last 10 years of preclinical studies
Due to the rise of multidrug-resistant infections in humans, phage therapy is gaining
renewed attention in Western medicine. Despite the increasing number of publications …
renewed attention in Western medicine. Despite the increasing number of publications …
Encapsulation and delivery of therapeutic phages
Delivery of therapeutic compounds to the site of action is crucial. While many chemical
substances such as beta-lactam antibiotics can reach therapeutic levels in most parts …
substances such as beta-lactam antibiotics can reach therapeutic levels in most parts …