Role of cardiolipin in mitochondrial signaling pathways

J Dudek - Frontiers in cell and developmental biology, 2017 - frontiersin.org
The phospholipid cardiolipin (CL) is an essential constituent of mitochondrial membranes
and plays a role in many mitochondrial processes, including respiration and energy …

OPA1 processing in cell death and disease–the long and short of it

T MacVicar, T Langer - Journal of cell science, 2016 - journals.biologists.com
The regulation of mitochondrial dynamics by the GTPase OPA1, which is located at the inner
mitochondrial membrane, is crucial for adapting mitochondrial function and preserving …

Prohibitin 2 is an inner mitochondrial membrane mitophagy receptor

Y Wei, WC Chiang, R Sumpter, P Mishra, B Levine - Cell, 2017 - cell.com
The removal of unwanted or damaged mitochondria by autophagy, a process called
mitophagy, is essential for key events in development, cellular homeostasis, tumor …

Mechanisms and roles of mitophagy in neurodegenerative diseases

Y Wang, N Liu, B Lu - CNS neuroscience & therapeutics, 2019 - Wiley Online Library
Mitochondria are double‐membrane‐encircled organelles existing in most eukaryotic cells
and playing important roles in energy production, metabolism, Ca2+ buffering, and cell …

Prohibitins: a critical role in mitochondrial functions and implication in diseases

A Signorile, G Sgaramella, F Bellomo, D De Rasmo - Cells, 2019 - mdpi.com
Prohibitin 1 (PHB1) and prohibitin 2 (PHB2) are proteins that are ubiquitously expressed,
and are present in the nucleus, cytosol, and mitochondria. Depending on the cellular …

Sha** the mitochondrial inner membrane in health and disease

L Colina‐Tenorio, P Horten, N Pfanner… - Journal of internal …, 2020 - Wiley Online Library
Mitochondria play central roles in cellular energetics, metabolism and signalling. Efficient
respiration, mitochondrial quality control, apoptosis and inheritance of mitochondrial DNA …

Non-classical ferroptosis inhibition by a small molecule targeting PHB2

W Yang, B Mu, J You, C Tian, H Bin, Z Xu… - Nature …, 2022 - nature.com
Ferroptosis is a new type of programmed cell death characterized by iron-dependent lipid
peroxidation. Ferroptosis inhibition is thought as a promising therapeutic strategy for a …

Alzheimer s disease and oxidative stress: a review

M Pohanka - Current medicinal chemistry, 2014 - ingentaconnect.com
Alzheimer´ s disease (AD) is a neurodegenerative disorder with no known cure and rapid
rise in incidence. The predominant cognitive impairment is currently treated using cognitive …

Multifaceted role of prohibitin in cell survival and apoptosis

YT Peng, P Chen, RY Ouyang, L Song - Apoptosis, 2015 - Springer
Human eukaryotic prohibitin (prohibitin-1 and prohibitin-2) is a membrane protein with
different cellular localizations. It is involved in multiple cellular functions, including energy …

A cytosolic network suppressing mitochondria-mediated proteostatic stress and cell death

X Wang, XJ Chen - Nature, 2015 - nature.com
Mitochondria are multifunctional organelles whose dysfunction leads to neuromuscular
degeneration and ageing. The multi-functionality poses a great challenge for understanding …