Adaptive immune receptor repertoire analysis
B cell and T cell receptor repertoires compose the adaptive immune receptor repertoire
(AIRR) of an individual. The AIRR is a unique collection of antigen-specific receptors that …
(AIRR) of an individual. The AIRR is a unique collection of antigen-specific receptors that …
Immunoglobulin germline gene variation and its impact on human disease
Immunoglobulins (Ig) play an important role in the immune system both when expressed as
antigen receptors on the cell surface of B cells and as antibodies secreted into extracellular …
antigen receptors on the cell surface of B cells and as antibodies secreted into extracellular …
Current advances in biopharmaceutical informatics: guidelines, impact and challenges in the computational developability assessment of antibody therapeutics
Therapeutic monoclonal antibodies and their derivatives are key components of clinical
pipelines in the global biopharmaceutical industry. The availability of large datasets of …
pipelines in the global biopharmaceutical industry. The availability of large datasets of …
The evolutionary and functional significance of germline immunoglobulin gene variation
The recombination between immunoglobulin (IG) gene segments determines an individual's
naïve antibody repertoire and, consequently,(auto) antigen recognition. Emerging evidence …
naïve antibody repertoire and, consequently,(auto) antigen recognition. Emerging evidence …
Genetic variation in the immunoglobulin heavy chain locus shapes the human antibody repertoire
Variation in the antibody response has been linked to differential outcomes in disease, and
suboptimal vaccine and therapeutic responsiveness, the determinants of which have not …
suboptimal vaccine and therapeutic responsiveness, the determinants of which have not …
IGHV allele similarity clustering improves genotype inference from adaptive immune receptor repertoire sequencing data
In adaptive immune receptor repertoire analysis, determining the germline variable (V) allele
associated with each T-and B-cell receptor sequence is a crucial step. This process is highly …
associated with each T-and B-cell receptor sequence is a crucial step. This process is highly …
Improving generalization of machine learning-identified biomarkers using causal modelling with examples from immune receptor diagnostics
Abstract Machine learning is increasingly used to discover diagnostic and prognostic
biomarkers from high-dimensional molecular data. However, a variety of factors related to …
biomarkers from high-dimensional molecular data. However, a variety of factors related to …
T cell receptor beta germline variability is revealed by inference from repertoire data
Background T and B cell receptor (TCR, BCR) repertoires constitute the foundation of
adaptive immunity. Adaptive immune receptor repertoire sequencing (AIRR-seq) is a …
adaptive immunity. Adaptive immune receptor repertoire sequencing (AIRR-seq) is a …
Reading the repertoire: Progress in adaptive immune receptor analysis using machine learning
The adaptive immune system holds invaluable information on past and present immune
responses in the form of B and T cell receptor sequences, but we are limited in our ability to …
responses in the form of B and T cell receptor sequences, but we are limited in our ability to …
simAIRR: simulation of adaptive immune repertoires with realistic receptor sequence sharing for benchmarking of immune state prediction methods
Background Machine learning (ML) has gained significant attention for classifying immune
states in adaptive immune receptor repertoires (AIRRs) to support the advancement of …
states in adaptive immune receptor repertoires (AIRRs) to support the advancement of …