Overcoming the translational crisis of contemporary psychiatry–converging phenomenological and spatiotemporal psychopathology

G Northoff, J Daub, D Hirjak - Molecular Psychiatry, 2023 - nature.com
Despite all neurobiological/neurocomputational progress in psychiatric research, recent
authors speak about a 'crisis of contemporary psychiatry'. Some argue that we do not yet …

Is depression a global brain disorder with topographic dynamic reorganization?

G Northoff, D Hirjak - Translational Psychiatry, 2024 - nature.com
Major depressive disorder (MDD) is characterized by a multitude of psychopathological
symptoms including affective, cognitive, perceptual, sensorimotor, and social. The neuronal …

[HTML][HTML] Brain correlates of depression, post-traumatic distress, and inflammatory biomarkers in COVID-19 survivors: a multimodal magnetic resonance imaging study

F Benedetti, M Palladini, M Paolini, E Melloni… - Brain, behavior, & …, 2021 - Elsevier
Psychiatric sequelae substantially contribute to the post-acute burden of disease associated
with COVID-19, persisting months after clearance of the virus. Brain imaging shows white …

Brain-wide changes in excitation-inhibition balance of major depressive disorder: a systematic review of topographic patterns of GABA-and glutamatergic alterations

YT Hu, ZL Tan, D Hirjak, G Northoff - Molecular Psychiatry, 2023 - nature.com
The excitation-inhibition (E/I) imbalance is an important molecular pathological feature of
major depressive disorder (MDD) as altered GABA and glutamate levels have been found in …

Biological factors influencing depression in later life: role of aging processes and treatment implications

SM Szymkowicz, AR Gerlach, D Homiack… - Translational …, 2023 - nature.com
Late-life depression occurring in older adults is common, recurrent, and malignant. It is
characterized by affective symptoms, but also cognitive decline, medical comorbidity, and …

Functional connectomics in depression: insights into therapies

Y Chai, YI Sheline, DJ Oathes, NL Balderston… - Trends in Cognitive …, 2023 - cell.com
Depression is a common mental disorder characterized by heterogeneous cognitive and
behavioral symptoms. The emerging research paradigm of functional connectomics has …

[HTML][HTML] Spatiotemporal neuroscience–what is it and why we need it

G Northoff, S Wainio-Theberge, K Evers - Physics of life reviews, 2020 - Elsevier
The excellent commentaries to our target paper hint upon three main issues,(i)
spatiotemporal neuroscience;(ii) neuro-mental relationship; and (iii) mind, brain, and world …

[HTML][HTML] Stress and its sequelae: An active inference account of the etiological pathway from allostatic overload to depression

I Arnaldo, AW Corcoran, KJ Friston… - … & Biobehavioral Reviews, 2022 - Elsevier
Survival requires the implementation of adaptive changes that demand energy resources.
The efficient regulation of energetic resources thus plays a critical role in enabling systems …

Reduction of higher-order occipital GABA and impaired visual perception in acute major depressive disorder

XM Song, XW Hu, Z Li, Y Gao, X Ju, DY Liu… - Molecular …, 2021 - nature.com
Major depressive disorder (MDD) is a complex state-dependent psychiatric illness for which
biomarkers linking psychophysical, biochemical, and psychopathological changes remain …

Spatiotemporal Psychopathology–An integrated brain-mind approach and catatonia

G Northoff, D Hirjak - Schizophrenia research, 2024 - Elsevier
Catatonia is featured by complex symptoms combining motor, affective and behavioral
phenomena as well as by its syndrome character with trans-diagnostic occurrence. It …