What is the significance of variant histology in urothelial carcinoma?
N Lobo, SF Shariat, CC Guo, MI Fernandez… - European urology …, 2020 - Elsevier
Context Urothelial carcinoma can exhibit a wide range of variant morphologies. Many
variants present diagnostic challenges and carry clinical implications that inform prognosis …
variants present diagnostic challenges and carry clinical implications that inform prognosis …
Genomic heterogeneity in bladder cancer: challenges and possible solutions to improve outcomes
Histological and molecular analyses of urothelial carcinoma often reveal intratumoural and
intertumoural heterogeneity at the genomic, transcriptional and cellular levels. Despite the …
intertumoural heterogeneity at the genomic, transcriptional and cellular levels. Despite the …
Variants and new entities of bladder cancer
A Lopez‐Beltran, V Henriques, R Montironi… - …, 2019 - Wiley Online Library
Pathological evaluation of bladder cancer typically reveals great tumour heterogeneity, and
therefore the common observation of urothelial carcinoma exhibiting a wide variety of …
therefore the common observation of urothelial carcinoma exhibiting a wide variety of …
Transcription Regulation of the Human Telomerase Reverse Transcriptase (hTERT) Gene
Embryonic stem cells and induced pluripotent stem cells have the ability to maintain their
telomere length via expression of an enzymatic complex called telomerase. Similarly, more …
telomere length via expression of an enzymatic complex called telomerase. Similarly, more …
[PDF][PDF] Urothelial carcinoma: Divergent differentiation and morphologic subtypes
Identifying the histologic subtypes and divergent differentiation in bladder cancer is
important to establish the correct diagnosis and classification and may also be clinically …
important to establish the correct diagnosis and classification and may also be clinically …
Report from the International Society of Urological Pathology (ISUP) consultation conference on molecular pathology of urogenital cancers. II. Molecular pathology of …
JI Warrick, MA Knowles, A Yves… - The American Journal …, 2020 - journals.lww.com
Abstract During the 2019 International Society of Urological Pathology Consultation
Conference on Molecular Pathology of Urogenital Cancer, the Working Group on Bladder …
Conference on Molecular Pathology of Urogenital Cancer, the Working Group on Bladder …
Mutations in TERT promoter and FGFR3 and telomere length in bladder cancer
Mutations in the promoter of the telomerase reverse transcriptase (TERT) and fibroblast
growth factor receptor 3 (FGFR3) genes constitute the most recurrent somatic alterations in …
growth factor receptor 3 (FGFR3) genes constitute the most recurrent somatic alterations in …
Biological and clinical perspectives of TERT promoter mutation detection on bladder cancer diagnosis and management
The telomerase reverse transcriptase (TERT) promoter mutations are associated with
increased TERT mRNA and TERT protein levels, telomerase activity, and shorter but stable …
increased TERT mRNA and TERT protein levels, telomerase activity, and shorter but stable …
Precision medicine in bladder cancer: present challenges and future directions
Bladder cancer (BC) is characterized by significant histopathologic and molecular
heterogeneity. The discovery of molecular pathways and knowledge of cellular mechanisms …
heterogeneity. The discovery of molecular pathways and knowledge of cellular mechanisms …
[HTML][HTML] Variant histology in bladder cancer: diagnostic and clinical implications
AJ Black, PC Black - Translational cancer research, 2020 - ncbi.nlm.nih.gov
Urothelial carcinoma differentiates into variant histological subtypes in approximately 25% of
cases. Since every histological variant has unique characteristics, including metastatic …
cases. Since every histological variant has unique characteristics, including metastatic …