Helical vasculogenesis driven by cell chirality

H Zhang, T Rahman, S Lu, AP Adam, LQ Wan - Science Advances, 2024 - science.org
The cellular helical structure is well known for its crucial role in development and disease.
Nevertheless, the underlying mechanism governing this phenomenon remains largely …

[HTML][HTML] Biomechanical modeling of cell chirality and symmetry breaking of biological systems

T Rahman, FD Peters, LQ Wan - Mechanobiology in medicine, 2024 - Elsevier
Accumulating evidence strongly suggests that cell chirality plays a pivotal role in driving left-
right (LR) symmetry breaking, a widespread phenomenon in living organisms. Whole …

Couple stresses and discrete potentials in the vertex model of cellular monolayers

OE Jensen, CK Revell - Biomechanics and modeling in mechanobiology, 2023 - Springer
The vertex model is widely used to simulate the mechanical properties of confluent epithelia
and other multicellular tissues. This inherently discrete framework allows a Cauchy stress to …

Lost in Rotation: How TiO2 and ZnO Nanoparticles Disrupt Coordinated Epithelial Cell Rotation

JYC Koh, L Chen, L Gong, SJ Tan, HW Hou, CY Tay - Small, 2024 - Wiley Online Library
Coordinated cell movement is a cardinal feature in tissue organization that highlights the
importance of cells working together as a collective unit. Disruptions to this synchronization …

Cell jamming regulates epithelial chiral morphogenesis

T Rahman, F Peters, LQ Wan - Journal of biomechanics, 2023 - Elsevier
Internal organs such as the heart demonstrate apparent left–right (LR) asymmetric
morphology and positioning. Cellular chirality and associated LR biased mechanical …

Structure formation induced by non-reciprocal cell–cell interactions in a multicellular system

B Bhattacherjee, M Hayakawa, T Shibata - Soft Matter, 2024 - pubs.rsc.org
Collective cellular behavior plays a crucial role in various biological processes, ranging from
developmental morphogenesis to pathological processes such as cancer metastasis. Our …

Dynamic self-organization of migrating cells under constraints by spatial confinement and epithelial integrity

T Hiraiwa - The European Physical Journal E, 2022 - Springer
Understanding how migrating cells can establish both dynamic structures and coherent
dynamics may provide mechanistic insights to study how living systems acquire complex …

Energetic scaling behavior of patterned epithelium

FD Peters, T Rahman, H Zhang, LQ Wan - Journal of Biomechanics, 2024 - Elsevier
Cellular monolayers display various degrees of coordinated motion ranging from the small
scale of just a few cells to large multi-cellular scales. This collective migration carries …

Epithelial cell chirality emerges through the dynamic concentric pattern of actomyosin cytoskeleton

T Yamamoto, T Ishibashi, Y Mimori-Kiyosue, S Hiver… - bioRxiv, 2023 - biorxiv.org
The chirality of tissues and organs is essential for their function and development. Tissue-
level chirality derives from the chirality of individual cells that comprise the tissue, and …

[PDF][PDF] Mechanobiology in Medicine

T Rahman, FD Peters, LQ Wan - researchgate.net
Accumulating evidence strongly suggests that cell chirality plays a pivotal role in driving left-
right (LR) symmetry breaking, a widespread phenomenon in living organisms. Whole …