Intravital microscopy has become increasingly popular over the past few decades because it
provides high-resolution and real-time information about complex biological processes …

Visualizing the cell cycle behavior of individual cells within living organisms can facilitate the
understanding of developmental processes such as pattern formation, morphogenesis, cell …

During development, animals generate distinct cell populations with specific identities,
functions, and morphologies. We mapped transcriptionally distinct populations across …

The adult zebrafish heart has a high capacity for regeneration following injury. However, the
composition of the regenerative niche has remained largely elusive. Here, we dissected the …

INTRODUCTION The developmental path by which a fertilized egg gives rise to the cells of a
multicellular organism is termed the cell lineage. In 1983, John Sulston and colleagues …

Extracellular vesicles (EVs) are released by most cell types but providing evidence for their
physiological relevance remains challenging due to a lack of appropriate model organisms …

Early embryonic development is driven exclusively by maternal gene products deposited
into the oocyte. Although critical in establishing early developmental programs, maternal …

CRISPR/Cas9 technology of genome editing has greatly facilitated the targeted inactivation
of genes in vitro and in vivo in a wide range of organisms. In zebrafish, it allows the rapid …

CRISPR-Cas9 enables efficient sequence-specific mutagenesis for creating somatic or
germline mutants of model organisms. Key constraints in vivo remain the expression and …

Hematopoietic stem and progenitor cells (HSPCs) can reconstitute and sustain the entire
blood system. We generated a highly specific transgenic reporter of HSPCs in zebrafish …