Intimal thickening, the accumulation of cells and extracellular matrix within the inner vessel
wall, is a physiological response to mechanical injury, increased wall stress, or chemical …

The adventitial layer surrounding the blood vessels has long been exclusively considered a
supporting tissue the main function of which is to provide adequate nourishment to the …

Vascular smooth muscle cell (VSMC) apoptosis occurs in many arterial diseases, including
aneurysm formation, angioplasty restenosis and atherosclerosis. Although VSMC apoptosis …

It is generally accepted that the de-differentiation of smooth muscle cells, from the contractile
to the proliferative/synthetic phenotype, has an important role during vascular remodelling …

The long term outcome of stent implantation is affected by a process called in stent
restenosis (ISR). Multiple contributory factors have been identified, but clear understanding …

Severe pulmonary arterial hypertension, whether idiopathic or secondary, is characterized
by structural alterations of microscopically small pulmonary arterioles. The vascular lesions …

Vascular remodeling stands for structural changes of the vessel wall in response to various
noxious stimuli, which results in reorganization of the vessel wall architecture. Luminal …

Previous studies have shown that mitofusin 2 (Mfn-2)(or hyperplasia suppressor gene
[HSG]) inhibits vascular smooth muscle cell (VSMC) proliferation. Here, we demonstrate that …

Apoptotic death of vascular cells is a prominent feature of blood vessel remodeling that
occurs during normal development and fibroproliferative disorders of the vessel wall. This …

Apoptosis, or programmed cell death, is a process through which multicellular organisms dis-
pose of cells efficiently. Much has been discovered about the molecular control of apoptosis …