Executive summary The 2024 update of the Lancet Commission on dementia provides new
hopeful evidence about dementia prevention, intervention, and care. As people live longer …

Executive summary Traumatic brain injury (TBI) has the highest incidence of all common
neurological disorders, and poses a substantial public health burden. TBI is increasingly …

Traumatic brain injury (TBI) is associated with a host of psychiatric and neurobehavioral
problems. As mortality rates have declined for severe TBI, attention has turned to the …

Traumatic brain injury (TBI) is a global health priority, associated with substantial burden.
Historically conceptualised as an injury event with finite recovery, TBI is now recognised as …

Activation of the innate immune system following pattern recognition receptor binding has
emerged as one of the major pathogenic mechanisms in neurodegenerative disease …

Neuroinflammatory and neurodegenerative disorders including Alzheimer's disease (AD),
Parkinson's disease (PD), traumatic brain injury (TBI) and Amyotrophic lateral sclerosis …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of
coronavirus disease 2019 (COVID-19), could affect brain structure and function. SARS-CoV …

The clearance function is essential for maintaining brain tissue homeostasis, and the
glymphatic system is the main pathway for removing brain interstitial solutes. Aquaporin-4 …

Central nervous system (CNS) accumulation of fibrillary deposits made of Amyloid β (A β),
hyperphosphorylated Tau or α-synuclein (α-syn), present either alone or in the form of mixed …

Astrocytes are essential for normal brain development and functioning. They respond to
brain injury and disease through a process referred to as reactive astrogliosis, where the …