Mammalian spermatogenesis is a complex biological process occurring in the seminiferous
tubules in the testis. This process represents a delicate balance between cell proliferation …

Male infertility is a widespread health problem affecting approximately 6%–8% of the male
population, and hypoxia may be a causative factor. In mammals, two types of hypoxia are …

Dysregulation of androgen-binding protein (ABP) is associated with a number of endocrine
and andrology diseases. However, the ABP metabolism in Sertoli cells is largely unknown …

In recent years, autophagy was found to regulate lipid metabolism through a process termed
lipophagy. Lipophagy modulates the degradation of cholesteryl esters to free cholesterol …

Abstract Study Objectives: Obstructive sleep apnea (OSA) is characterized by intermittent
hypoxia and oxidative stress. However, it is unknown whether intermittent hypoxia mimicking …

Endocrine is an important and tightly regulated system for maintaining body homeostasis.
Endocrine glands produce hormones, which are released into blood stream to guide the …

Increased testicular temperature reduces percentages of morphologically normal and motile
sperm and fertility. Specific sperm defects appear at consistent intervals after testicular …

Aims Many studies demonstrated reproductive damage in men residing in plains who are
exposed to hypoxia at high altitudes. However, little is known about mechanisms between …

Male fertility disorders play a key role in half of all infertility cases. Reduction in testosterone
induced by hypoxia might cause diseases in reproductive system and other organs. Hypoxic …

Testicular compartment syndrome (TCS) refers to the impairment of microcirculation in the
testicle due to either increased venous resistance or extraluminal compression, which leads …