Monoclonal antibodies (mAbs) are often selected from antigen-specific single B cells
derived from different hosts, which are notably short-lived in ex vivo culture conditions and …

Monoclonal antibodies (mAbs) are a crucial asset for human health and modern medicine,
however, the repeated administration of mAbs can be highly immunogenic. Drug …

B cell receptor (BCR) sequencing is a powerful tool for interrogating immune responses to
infection and vaccination, but it provides limited information about the antigen specificity of …

Mining the antibody repertoire of plasma cells and plasmablasts could enable the discovery
of useful antibodies for therapeutic or research purposes. We present a method for high …

To address the ongoing SARS-CoV-2 pandemic and prepare for future coronavirus
outbreaks, understanding the protective potential of epitopes conserved across SARS-CoV …

Antibody display technologies enable the successful isolation of antigen-specific antibodies
with therapeutic potential. The key feature that facilitates the selection of an antibody with …

T cell immunotherapy holds significant challenges in solid tumors, mainly due to the T cells'
low activation and the decreased synthesis–release of therapeutic proteins, including …

Monoclonal antibodies are increasingly used to prevent and treat viral infections and are
pivotal in pandemic response efforts. Antibody-secreting cells (ASCs; plasma cells and …

Obtaining full-length antibody heavy-and light-chain variable regions from individual B cells
at scale remains a challenging problem. Here we use high-throughput single-cell B-cell …

Antibodies are vital proteins of the immune system that recognize potentially harmful
molecules and initiate their removal. Mammals can efficiently create vast numbers of …