Transmembrane proteins comprise~ 30% of the mammalian proteome, mediating
metabolism, signalling, transport and many other functions required for cellular life. The …

The lipid raft hypothesis postulates that lipid–lipid interactions can laterally organize
biological membranes into domains of distinct structures, compositions, and functions. This …

Cellular plasma membranes are laterally heterogeneous, featuring a variety of distinct
subcompartments that differ in their biophysical properties and composition. A large number …

Many enveloped viruses induce multinucleated cells (syncytia), reflective of membrane
fusion events caused by the same machinery that underlies viral entry. These syncytia are …

Eukaryotic plasma membranes are compartmentalized into functional lateral domains,
including lipid-driven membrane rafts. Rafts are involved in most plasma membrane …

The study of extracellular vesicles (EVs) is a rapidly evolving field, owing in large part to
recent advances in the realization of their significant contributions to normal physiology and …

Cell membranes are composed of a lipid bilayer, containing proteins that span the bilayer
and/or interact with the lipids on either side of the two leaflets. Although recent advances in …

Since its initial formalization nearly 20 years ago, the concept of lipid rafts has generated a
tremendous amount of attention and interest and nearly as much controversy. The …

The plasma membrane in eukaryotic cells contains microdomains that are enriched in
certain glycosphingolipids, gangliosides, and sterols (such as cholesterol) to form …

Dietary fat promotes pathological insulin resistance through chronic inflammation,,. The
inactivation of inflammatory proteins produced by macrophages improves diet-induced …