Interlinked and fundamental aging processes appear to be a root-cause contributor to many
disorders and diseases. One such process is cellular senescence, which entails a state of …

Cellular senescence is a cell fate triggered in response to stress and is characterized by
stable cell-cycle arrest and a hypersecretory state. It has diverse biological roles, ranging …

Senescent cell accumulation has been implicated in the pathogenesis of aging-associated
diseases, including cancer. The mechanism that prevents the accumulation of senescent …

Senescence drives organismal aging, yet the deep characterization of senescent cells in
vivo remains incomplete. Here, we apply mass cytometry by time-of-flight using carefully …

Clearance of senescent cells (SnCs) can prevent several age-related pathologies, including
bone loss. However, the local versus systemic roles of SnCs in mediating tissue dysfunction …

It is widely accepted that senescent cells accumulate with aging. They are characterized by
replicative arrest and the release of a myriad of factors commonly called the senescence …

Aging is a biological feature that is characterized by gradual degeneration of function in
cells, tissues, organs, or an intact organism due to the accumulation of environmental factors …

Closely associated with aging and age-related disorders, cellular senescence (CS) is the
inability of cells to proliferate due to accumulated unrepaired cellular damage and …

Senescent cell accumulation has been observed in age-associated diseases including
cardiovascular diseases. Senescent cells lack proliferative capacity and secrete senescence …

The musculoskeletal system supports the movement of the entire body and provides blood
production while acting as an endocrine organ. With aging, the balance of bone …