Interplay between mechanics and signalling in regulating cell fate

H De Belly, EK Paluch, KJ Chalut - Nature Reviews Molecular Cell …, 2022‏ - nature.com
Mechanical signalling affects multiple biological processes during development and in adult
organisms, including cell fate transitions, cell migration, morphogenesis and immune …

Mechanical regulation of chromatin and transcription

S Dupont, SA Wickström - Nature Reviews Genetics, 2022‏ - nature.com
Cells and tissues generate and are exposed to various mechanical forces that act across a
range of scales, from tissues to cells to organelles. Forces provide crucial signals to inform …

Mechanical forces direct stem cell behaviour in development and regeneration

KH Vining, DJ Mooney - Nature reviews Molecular cell biology, 2017‏ - nature.com
Stem cells and their local microenvironment, or niche, communicate through mechanical
cues to regulate cell fate and cell behaviour and to guide developmental processes. During …

Mechanobiology of YAP and TAZ in physiology and disease

T Panciera, L Azzolin, M Cordenonsi… - Nature reviews Molecular …, 2017‏ - nature.com
A growing body of evidence suggests that mechanical signals emanating from the cell's
microenvironment are fundamental regulators of cell behaviour. Moreover, at the …

[HTML][HTML] The instructive extracellular matrix of the lung: basic composition and alterations in chronic lung disease

G Burgstaller, B Oehrle, M Gerckens… - European …, 2017‏ - publications.ersnet.org
The pulmonary extracellular matrix (ECM) determines the tissue architecture of the lung, and
provides mechanical stability and elastic recoil, which are essential for physiological lung …

Biodegradable polymers as the pivotal player in the design of tissue engineering scaffolds

F Zhang, MW King - Advanced healthcare materials, 2020‏ - Wiley Online Library
Biodegradable polymers play a pivotal role in in situ tissue engineering. Utilizing various
technologies, researchers have been able to fabricate 3D tissue engineering scaffolds using …

[HTML][HTML] Extracellular matrix: a dynamic microenvironment for stem cell niche

F Gattazzo, A Urciuolo, P Bonaldo - Biochimica et Biophysica Acta (BBA) …, 2014‏ - Elsevier
Background Extracellular matrix (ECM) is a dynamic and complex environment
characterized by biophysical, mechanical and biochemical properties specific for each …

Nuclear lamin-A scales with tissue stiffness and enhances matrix-directed differentiation

J Swift, IL Ivanovska, A Buxboim, T Harada… - Science, 2013‏ - science.org
Introduction Tissues can be soft like brain, bone marrow, and fat, which bear little
mechanical stress, or stiff like muscle, cartilage, and bone, which sustain high levels of …

Sterol regulatory element binding protein 1 couples mechanical cues and lipid metabolism

R Bertolio, F Napoletano, M Mano… - Nature …, 2019‏ - nature.com
Sterol regulatory element binding proteins (SREBPs) are a family of transcription factors that
regulate lipid biosynthesis and adipogenesis by controlling the expression of several …

Role of YAP/TAZ in cell-matrix adhesion-mediated signalling and mechanotransduction

S Dupont - Experimental cell research, 2016‏ - Elsevier
Signalling from the extracellular matrix (ECM) is a fundamental cellular input that sustains
proliferation, opposes cell death and regulates differentiation. Through integrins, cells …