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The immune profile of major dysmood disorder: proof of concept and mechanism using the precision nomothetic psychiatry approach
Major depressive disorder and a major depressive episode (MDD/MDE) are characterized
by activation of the immune-inflammatory response system (IRS) and the compensatory …
by activation of the immune-inflammatory response system (IRS) and the compensatory …
[HTML][HTML] T helper-1 activation via interleukin-16 is a key phenomenon in the acute phase of severe, first-episode major depressive disorder and suicidal behaviors
Background Immune-inflammatory pathways in major depressive disorder are confined to
the major dysmood disorder (MDMD) phenotype (Maes et al., 2022). No studies have …
the major dysmood disorder (MDMD) phenotype (Maes et al., 2022). No studies have …
The physio-affective phenome of major depression is strongly associated with biomarkers of astroglial and neuronal projection toxicity which in turn are associated …
HK Al-Hakeim, TH Al-Naqeeb, AF Almulla… - Journal of affective …, 2023 - Elsevier
Background Major depressive disorder (MDD) is characterized by elevated activity of
peripheral neuro-immune and neuro-oxidative pathways, which may cause neuro-affective …
peripheral neuro-immune and neuro-oxidative pathways, which may cause neuro-affective …
[HTML][HTML] Adverse childhood experiences predict the phenome of affective disorders and these effects are mediated by staging, neuroimmunotoxic and growth factor …
Adverse childhood experiences (ACEs) enhance pro-inflammatory and pro-oxidant
responses. In affective disorders, recent precision nomothetic psychiatry studies disclosed …
responses. In affective disorders, recent precision nomothetic psychiatry studies disclosed …
Adverse childhood experiences and recent negative events are associated with activated immune and growth factor pathways, the phenome of first episode major …
This research assessed the effects of adverse childhood experiences (ACEs) and negative
life events (NLEs) on forty-eight cytokines/chemokines/growth factors, in 71 FE-MDMD …
life events (NLEs) on forty-eight cytokines/chemokines/growth factors, in 71 FE-MDMD …
In major dysmood disorder, physiosomatic, chronic fatigue and fibromyalgia symptoms are driven by immune activation and increased immune-associated …
Major depressive disorder (MDD) is accompanied by activated neuro-immune pathways,
increased physiosomatic and chronic fatigue-fibromyalgia (FF) symptoms. The most severe …
increased physiosomatic and chronic fatigue-fibromyalgia (FF) symptoms. The most severe …
Role of T and B lymphocyte cannabinoid type 1 and 2 receptors in major depression and suicidal behaviours
M Maes, M Rachayon, K Jirakran… - Acta …, 2024 - cambridge.org
Early flow cytometry studies revealed T cell activation in major depressive disorder (MDD).
MDD is characterised by activation of the immune-inflammatory response system (IRS) and …
MDD is characterised by activation of the immune-inflammatory response system (IRS) and …
[HTML][HTML] Cannabidiol in Foods and Food Supplements: Evaluation of Health Risks and Health Claims
BE Engeli, DW Lachenmeier, P Diel, S Guth… - Nutrients, 2025 - pmc.ncbi.nlm.nih.gov
Background: Cannabidiol (CBD) is a cannabinoid present in the hemp plant (Cannabis
sativa L.). Non-medicinal CBD oils with typically 5–40% CBD are advertised for various …
sativa L.). Non-medicinal CBD oils with typically 5–40% CBD are advertised for various …
[HTML][HTML] Cannabidiolic acid in hemp seed oil table spoon and beyond
E Nigro, MT Pecoraro, M Formato, S Piccolella… - Molecules, 2022 - mdpi.com
Cannabidiolic acid (CBDA) is the main precannabinoid in industrial hemp. It represents a
common constituent of hemp seed oil, but mainly abundant in the aerial parts of the plant …
common constituent of hemp seed oil, but mainly abundant in the aerial parts of the plant …
Medical cannabis use and inflammatory cytokines and chemokines among adult chronic pain patients
P Ajrawat, Y Yang, E Wasilewski, T Leroux… - Cannabis and …, 2024 - liebertpub.com
Background: Utilizing cannabis as a therapeutic option for chronic pain (CP) has increased
significantly. However, data regarding the potential immunomodulatory effects of cannabis in …
significantly. However, data regarding the potential immunomodulatory effects of cannabis in …