Ovarian cancer immunotherapy and personalized medicine

S Morand, M Devanaboyina, H Staats… - International Journal of …, 2021 - mdpi.com
Ovarian cancer response to immunotherapy is limited; however, the evaluation of
sensitive/resistant target treatment subpopulations based on stratification by tumor …

Role of immunotherapy in triple-negative breast cancer

TE Keenan, SM Tolaney - Journal of the National Comprehensive Cancer …, 2020 - jnccn.org
Immune checkpoint inhibitors (ICIs) have led to durable clinical remissions in many
metastatic cancers. However, the single-agent efficacy of ICIs in breast cancer is low …

Peptide-based vaccines: current progress and future challenges

RJ Malonis, JR Lai, O Vergnolle - Chemical reviews, 2019 - ACS Publications
Vaccines have had a profound impact on the management and prevention of infectious
disease. In addition, the development of vaccines against chronic diseases has attracted …

Exploiting the folate receptor α in oncology

M Scaranti, E Cojocaru, S Banerjee… - Nature reviews clinical …, 2020 - nature.com
Folate receptor α (FRα) came into focus as an anticancer target many decades after the
successful development of drugs targeting intracellular folate metabolism, such as …

Immunotherapy in triple negative breast cancer: beyond checkpoint inhibitors

Y Abdou, A Goudarzi, JX Yu, S Upadhaya… - NPJ Breast …, 2022 - nature.com
The development of immunotherapy agents has revolutionized the field of oncology. The
only FDA-approved immunotherapeutic approach in breast cancer consists of immune …

[HTML][HTML] Aptamer grafted nanoparticle as targeted therapeutic tool for the treatment of breast cancer

A Sheikh, S Md, P Kesharwani - Biomedicine & Pharmacotherapy, 2022 - Elsevier
Breast carcinomas repeat their number and grow exponentially making it extremely frequent
malignancy among women. Approximately, 70–80% of early diagnosed or non-metastatic …

Nanotechnology-based siRNA delivery strategies for treatment of triple negative breast cancer

R Chadar, P Kesharwani - International Journal of Pharmaceutics, 2021 - Elsevier
Triple negative breast cancer (TNBC) is a subtype of breast cancer characterized by
absence of estrogen (ER) receptor, progesterone (PR) receptor, and human epidermal …

Peptides for vaccine development

IW Hamley - ACS Applied Bio Materials, 2022 - ACS Publications
This review discusses peptide epitopes used as antigens in the development of vaccines in
clinical trials as well as future vaccine candidates. It covers peptides used in potential …

Th17-inducing autologous dendritic cell vaccination promotes antigen-specific cellular and humoral immunity in ovarian cancer patients

MS Block, AB Dietz, MP Gustafson, KR Kalli… - Nature …, 2020 - nature.com
In ovarian cancer (OC), IL-17-producing T cells (Th17s) predict improved survival, whereas
regulatory T cells predict poorer survival. We previously developed a vaccine whereby …

Bacterial outer membrane vesicles as a candidate tumor vaccine platform

S Wang, J Guo, Y Bai, C Sun, Y Wu, Z Liu… - Frontiers in …, 2022 - frontiersin.org
Cancer represents a serious concern for human life and health. Due to drug resistance and
the easy metastasis of tumors, there is urgent need to develop new cancer treatment …