Tutorial: best practices and considerations for mass-spectrometry-based protein biomarker discovery and validation
Mass-spectrometry-based proteomic analysis is a powerful approach for discovering new
disease biomarkers. However, certain critical steps of study design such as cohort selection …
disease biomarkers. However, certain critical steps of study design such as cohort selection …
Cancer biomarker detection: recent achievements and challenges
L Wu, X Qu - Chemical Society Reviews, 2015 - pubs.rsc.org
The early detection of cancer can significantly reduce cancer mortality and saves lives. Thus,
a great deal of effort has been devoted to the exploration of new technologies to detect early …
a great deal of effort has been devoted to the exploration of new technologies to detect early …
Proteogenomic analysis of human colon cancer reveals new therapeutic opportunities
We performed the first proteogenomic study on a prospectively collected colon cancer
cohort. Comparative proteomic and phosphoproteomic analysis of paired tumor and normal …
cohort. Comparative proteomic and phosphoproteomic analysis of paired tumor and normal …
Protein analysis by shotgun/bottom-up proteomics
According to Genome Sequencing Project statistics (http://www. ncbi. nlm. nih.
gov/genomes/static/gpstat. html), as of February 16, 2012, complete gene sequences have …
gov/genomes/static/gpstat. html), as of February 16, 2012, complete gene sequences have …
Targeted peptide measurements in biology and medicine: best practices for mass spectrometry-based assay development using a fit-for-purpose approach
Adoption of targeted mass spectrometry (MS) approaches such as multiple reaction
monitoring (MRM) to study biological and biomedical questions is well underway in the …
monitoring (MRM) to study biological and biomedical questions is well underway in the …
Quantitative analysis of peptides and proteins in biomedicine by targeted mass spectrometry
MA Gillette, SA Carr - Nature methods, 2013 - nature.com
Targeted mass spectrometry (MS) is becoming widely used in academia and in
pharmaceutical and biotechnology industries for sensitive and quantitative detection of …
pharmaceutical and biotechnology industries for sensitive and quantitative detection of …
Multi-scale signaling and tumor evolution in high-grade gliomas
Although genomic anomalies in glioblastoma (GBM) have been well studied for over a
decade, its 5-year survival rate remains lower than 5%. We seek to expand the molecular …
decade, its 5-year survival rate remains lower than 5%. We seek to expand the molecular …
Clinical potential of mass spectrometry-based proteogenomics
Cancer genomics research aims to advance personalized oncology by finding and targeting
specific genetic alterations associated with cancers. In genome-driven oncology, treatments …
specific genetic alterations associated with cancers. In genome-driven oncology, treatments …
Advances in targeted proteomics and applications to biomedical research
Targeted proteomics technique has emerged as a powerful protein quantification tool in
systems biology, biomedical research, and increasing for clinical applications. The most …
systems biology, biomedical research, and increasing for clinical applications. The most …
Single-molecule detection of protein efflux from microorganisms using fluorescent single-walled carbon nanotube sensor arrays
A distinct advantage of nanosensor arrays is their ability to achieve ultralow detection limits
in solution by proximity placement to an analyte. Here, we demonstrate label-free detection …
in solution by proximity placement to an analyte. Here, we demonstrate label-free detection …