Genome-wide association studies and fine map** of candidate regions have rapidly
advanced our understanding of the genetic basis of systemic lupus erythematosus (SLE) …

Short segments of identity by descent (IBD) between individuals with no known relationship
can be detected using genome-wide single nucleotide polymorphism data and recently …

The human genome is a highly dynamic structure that shows a wide range of genetic
polymorphic variation. Unlike other types of structural variation, little is known about …

There has recently been considerable interest in detecting natural selection in the human
genome. Selection will usually tend to increase identity-by-descent (IBD) among individuals …

Mechanisms that suppress recombination are known to help maintain species barriers by
preventing the breakup of coadapted gene combinations. The sympatric butterfly species …

Studies of recombination and how it varies depend crucially on accurate recombination
maps. We propose a new approach for constructing high-resolution maps of relative …

Genomic inversions are an increasingly recognized source of genetic variation. However, a
lack of reliable high-throughput genoty** assays for these structures has precluded a full …

Despite the significant advances made over the last few years in map** inversions with
the advent of paired-end sequencing approaches, our understanding of the prevalence and …

Background Inversion polymorphisms constitute an evolutionary puzzle: they should
increase embryo mortality in heterokaryotypic individuals but still they are widespread in …

Inversion polymorphisms have important phenotypic and evolutionary consequences in
humans. Two different methodologies have been used to infer inversions from SNP dense …