Cancer cachexia: molecular mechanisms and treatment strategies

T Setiawan, IN Sari, YT Wijaya, NM Julianto… - Journal of hematology & …, 2023 - Springer
Muscle wasting is a consequence of physiological changes or a pathology characterized by
increased catabolic activity that leads to progressive loss of skeletal muscle mass and …

Neuromuscular junction transmission failure in aging and sarcopenia: The nexus of the neurological and muscular systems

WD Arnold, BC Clark - Ageing research reviews, 2023 - Elsevier
Sarcopenia, or age-related decline in muscle form and function, exerts high personal,
societal, and economic burdens when untreated. Integrity and function of the neuromuscular …

Disruption of Neuromuscular Junction Following Spinal Cord Injury and Motor Neuron Diseases

C Nemeth, NL Banik, A Haque - International Journal of Molecular …, 2024 - mdpi.com
The neuromuscular junction (NMJ) is a crucial structure that connects the cholinergic motor
neurons to the muscle fibers and allows for muscle contraction and movement. Despite the …

New intranasal and injectable gene therapy for healthy life extension

DK Jaijyan, A Selariu, R Cruz-Cosme, M Tong… - Proceedings of the …, 2022 - pnas.org
As the global elderly population grows, it is socioeconomically and medically critical to
provide diverse and effective means of mitigating the impact of aging on human health …

Putting some muscle into sarcopenia—the pathogenesis, assessment and clinical impact of muscle loss in patients with inflammatory bowel disease

SL Gold, M Raman, BE Sands… - Alimentary …, 2023 - Wiley Online Library
Background Sarcopenia, a loss of skeletal muscle mass or function, affects up to 50% of
patients with inflammatory bowel disease (IBD) and is associated with poor clinical …

Multimodal learning for map** genotype–phenotype dynamics

F Khodaee, R Zandie, ER Edelman - Nature Computational Science, 2025 - nature.com
How complex phenotypes emerge from intricate gene expression patterns is a fundamental
question in biology. Integrating high-content genoty** approaches such as single-cell …

Neuromuscular junction dysfunction in Lafora disease

M Shukla, D Chugh, S Ganesh - Disease Models & …, 2024 - journals.biologists.com
Lafora disease (LD), a fatal neurodegenerative disorder, is caused by mutations in the
EPM2A gene encoding laforin phosphatase or NHLRC1 gene encoding malin ubiquitin …

Effects of soy milk in conjunction with resistance training on physical performance and skeletal muscle regulatory markers in older men

N Bijeh, M Mohammadnia-Ahmadi… - Biological Research …, 2022 - journals.sagepub.com
Purpose: We aimed to determine the effects of 12 weeks of soy milk consumption combined
with resistance training (RT) on body composition, physical performance, and skeletal …

[HTML][HTML] Follistatin-respiratory connection predicting all-cause mortality among community-dwelling middle-to-old age individuals: Results from the I-Lan Longitudinal …

HC Shen, WJ Lee, CY Sun, WK Yu, WC Chen… - The Journal of nutrition …, 2024 - Elsevier
Objectives The link between aging and pulmonary function decline is well-established, but
the underlying mechanisms have yet to be fully revealed. Serum follistatin, a myokine …

The reign of follistatin in tumors and their microenvironment: implications for drug resistance

J Sosa, A Oyelakin, S Sinha - Biology, 2024 - mdpi.com
Simple Summary Within the extracellular milieu surrounding cancer cells exists an
ecosystem of heterogeneous cell populations that dictate tumor growth and survival via cell …