Mammalian cells respond to stress by activating mechanisms that support cellular functions
and hence maintain microenvironmental and organismal homeostasis. Intracellular …

Cells rely on the endoplasmic reticulum (ER) to fold and assemble newly synthesized
transmembrane and secretory proteins—essential for cellular structure–function and for both …

The thrombospondin (Thbs) family of secreted matricellular proteins are stress-and injury-
induced mediators of cellular attachment dynamics and extracellular matrix protein …

Skeletal muscle is the most abundant tissue in the human body and can adapt its mass as a
consequence of physical activity, metabolism, growth factors, and disease conditions …

The growth of skeletal muscle relies on a delicate equilibrium between protein synthesis and
degradation; however, how proteostasis is managed in the endoplasmic reticulum (ER) is …

Exercise training is well known to improve physical fitness and to combat chronic diseases
and aging related disorders. Part of this is thought to be mediated by myokines, muscle …

Abstract Activating transcription factor 4 (ATF4) is a multifunctional transcription regulatory
protein in the basic leucine zipper superfamily. ATF4 can be expressed in most if not all …

Skeletal muscle is a highly plastic tissue in the human body that undergoes extensive
adaptation in response to environmental cues, such as physical activity, metabolic …

Aging has been viewed both as a random process due to accumulation of molecular and
cellular damage over time and as a programmed process linked to cellular pathway …

Mitochondrial dysfunction is associated with activation of the integrated stress response
(ISR) but the underlying triggers remain unclear. We systematically combined acute …