[HTML][HTML] Osteoarthritis bone marrow lesions

DA Walsh, N Sofat, A Guermazi, DJ Hunter - Osteoarthritis and cartilage, 2023 - Elsevier
Assessment and treatment of Bone Marrow Lesions (BMLs) could ultimately make step
changes to the lives of people with osteoarthritis (OA). We here review the imaging and …

Pathological progression of osteoarthritis: a perspective on subchondral bone

X Li, W Chen, D Liu, P Chen, S Wang, F Li, Q Chen… - Frontiers of …, 2024 - Springer
Osteoarthritis (OA) is a degenerative bone disease associated with aging. The rising global
aging population has led to a surge in OA cases, thereby imposing a significant …

MSCs-laden silk Fibroin/GelMA hydrogels with incorporation of platelet-rich plasma for chondrogenic construct

D Chen, P Chang, P Ding, S Liu, Q Rao, OV Okoro… - Heliyon, 2023 - cell.com
Repair of osteochondral defects and regeneration of cartilage is a major challenge. In this
work, the mesenchymal stem cells (MSCs)-laden hydrogel was designed using silk fibroin …

Bone marrow lesions in osteoarthritis: biomarker or treatment target? A narrative review

L Ge, X Zhang, R Zhu, G Cai - Skeletal Radiology, 2024 - Springer
Osteoarthritis (OA) is a leading cause of pain, functional impairment, and disability in older
adults. However, there are no effective treatments to delay and reverse OA. Magnetic …

Radiomics analysis using magnetic resonance imaging of bone marrow edema for diagnosing knee osteoarthritis

X Li, W Chen, D Liu, P Chen, P Li, F Li… - … in Bioengineering and …, 2024 - frontiersin.org
This study aimed to develop and validate a bone marrow edema model using a magnetic
resonance imaging-based radiomics nomogram for the diagnosis of osteoarthritis. Clinical …

Bone marrow lesions: plugging the holes in our knowledge using animal models

RT Hansen, C Chenu, N Sofat… - Nature Reviews …, 2023 - nature.com
Bone marrow lesions (BMLs), which are early signs of osteoarthritis (OA) that are associated
with the presence, onset and severity of pain, represent an emerging imaging biomarker and …

[HTML][HTML] Bone marrow lesions in osteoarthritis: From basic science to clinical implications

X Shi, Y Mai, X Fang, Z Wang, S Xue, H Chen, Q Dang… - Bone Reports, 2023 - Elsevier
Osteoarthritis (OA) is the most prevalent musculoskeletal disease characterized by multiple
joint structure damages, including articular cartilage, subchondral bone and synovium …

Biological targets of multimolecular therapies in middle-age osteoarthritis

I Andia, L Atilano, N Maffulli - Sports Medicine and Arthroscopy …, 2022 - journals.lww.com
Knee osteoarthritis (OA) is a common condition, prevalent in middle-agedness, associated
with chronic pain and impaired quality of life. Two interrelated biological processes fuel early …

Inflammation and subsequent nociceptor sensitization in the bone marrow are involved in an animal model of osteoarthritis pain

T Murakami, T Ishida, S Tanaka, J Nakayama… - Life Sciences, 2023 - Elsevier
Aims This study aimed to determine whether pathological changes in the bone marrow
cause Osteoarthritis (OA) pain based on magnetic resonance imaging (MRI) …

Enhancing autophagy and energy metabolism in the meniscus can delay the occurrence of PTOA in ACLT rat

H Zhu, H Liu, X Chen, X Xu, S Zhang… - Frontiers in Cell and …, 2022 - frontiersin.org
Osteoarthritis (OA) is a progressive degenerative joint disease characterized by the
destruction of the articular cartilage, meniscus and the like. Autophagy and cellular energy …