Airway inflammation, airflow obstruction, and bronchial hyperresponsiveness are
characteristic phenotypic features of asthma. Clinically, airflow obstruction in asthma often is …

Agonists activating β2-adrenoceptors (β2ARs) on airway smooth muscle (ASM) are the drug
of choice for rescue from acute bronchoconstriction in patients with both asthma and chronic …

Both structural and inflammatory cells are capable of secreting transforming growth factor
(TGF)‐β and expressing TGF‐β receptors. TGF‐β can induce multiple cellular responses …

Rationale: Histologic stains have been used as the gold standard to visualize extracellular
matrix (ECM) changes associated with airway remodeling in asthma, yet they provide no …

Asthma is a chronic inflammatory airway disorder characterized by airway
hyperresponsiveness and reversible airflow obstruction. Subgroups of asthma patients …

Asthmatic airway remodeling is the pathophysiological modifications of the normal airway
wall structure which include changes in the composition and organization of its cellular and …

Structural changes reported in the airways of asthmatics include epithelial fragility, goblet
cell hyperplasia, enlarged submucosal mucus glands, angiogenesis, increased matrix …

Airway remodeling can be defined as changes in the composition, content, and organization
of the cellular and molecular constituents of the airway wall. Airway remodeling is a …

Genetic variants in the vitamin D receptor (VDR) gene were recently associated with asthma.
The biological mechanisms explaining this association are unknown but are likely to involve …

The chronic inflammatory response within the airways of asthmatics is associated with
structural changes termed airway remodeling. This remodeling process is a key feature of …