Specific cell states in metazoans are established by the symphony of gene expression
programs that necessitate intricate synergic interactions between transcription factors and …

Histones are integral components of eukaryotic chromatin that have a pivotal role in the
organization and function of the genome. The dynamic regulation of chromatin involves the …

Nucleosomes, the basic structural units of chromatin, hinder recruitment and activity of
various DNA repair proteins, necessitating modifications that enhance DNA accessibility …

Histone post-translational modifications (PTMs) play a critical role in chromatin regulation. It
has been proposed that these PTMs form localized 'codes' that are read by specialized …

The N-terminal tails of histones protrude from the nucleosome core and are target sites for
histone modifications, such as acetylation and methylation. Histone acetylation is …

The fundamental repeat unit of chromatin, the nucleosome, consists of approximately 147
base pairs of double-stranded DNA and a histone protein octamer containing two copies …

Infertility affects millions of couples worldwide and has a profound impact not only on their
families, but also on communities. Telomere attrition has been associated with infertility …

Epigenetic modifications of histone N-terminal tails play a critical role in regulating the
chromatin structure and biological processes such as transcription and DNA repair. One of …

Polyamines (PAs) are important molecules that determine cell longevity or death. Studies
have shown that nutritional supplementation with spermidine can reduce age-related …

Intrinsically disordered regions (IDRs) represent at least one-third of the human proteome
and defy the established structure-function paradigm. Because IDRs often have limited …