Folate receptor α (FRα) is a membrane‐bound protein with high affinity for binding and
transporting physiologic levels of folate into cells. Folate is a basic component of cell …

Folate is a B vitamin necessary for basic biological functions, including rapid cell turnover
occurring in cancer cell proliferation. Though the role of folate as a causative versus …

Introduction 3. Expression of FR in normal reproductive tissues 4. Role of FR during
pregnancy and lactation 4.1. Trans-placental folate uptake 4.2. Embryonal development 4.3 …

Background In this retrospective study we evaluated the respective correlations and clinical
relevance of FOLR1 mRNA expression, FOLR1 promoter specific methylation and global …

Abstract Purpose: Raltitrexed, pemetrexed, lometrexol, and ZD9331 are antifolate drugs
transported into cells via the ubiquitously expressed reduced-folate carrier. They display …

KLF8 (Krüppel-like factor 8) is a transcription factor downstream of focal adhesion kinase
(FAK) important in the regulation of the cell cycle and also plays a critical role in oncogenic …

PURPOSE: We conducted a randomised phase II study to assess the safety and efficacy of
standard versus high-dose pemetrexed in platinum-resistant epithelial ovarian cancer (PR …

Caveolin-1 (cav-1), a member of a protein family associated mainly with cell membrane
microdomains in many cell types, acts as a tumor suppressor in ovarian carcinoma cells …

We recently identified HSulf-1 as a down-regulated gene in ovarian carcinomas. Our
previous analysis indicated that HSulf-1 inactivation in ovarian cancers is partly mediated by …

Among all available lipid based nanoparticulate systems, the success of liposomal drug
delivery system is evident by the number of liposomal products available in the market or …