Short-chain fatty acids: linking diet, the microbiome and immunity

ER Mann, YK Lam, HH Uhlig - Nature Reviews Immunology, 2024 - nature.com
The short-chain fatty acids (SCFAs) butyrate, propionate and acetate are microbial
metabolites and their availability in the gut and other organs is determined by environmental …

Microbiota in health and diseases

K Hou, ZX Wu, XY Chen, JQ Wang, D Zhang… - Signal transduction and …, 2022 - nature.com
The role of microbiota in health and diseases is being highlighted by numerous studies
since its discovery. Depending on the localized regions, microbiota can be classified into …

Gut microbiota and short chain fatty acids: implications in glucose homeostasis

P Portincasa, L Bonfrate, M Vacca… - International journal of …, 2022 - mdpi.com
Gut microbiota encompasses a wide variety of commensal microorganisms consisting of
trillions of bacteria, fungi, and viruses. This microbial population coexists in symbiosis with …

[HTML][HTML] Butyrate's role in human health and the current progress towards its clinical application to treat gastrointestinal disease

K Hodgkinson, F El Abbar, P Dobranowski… - Clinical Nutrition, 2023 - Elsevier
Butyrate is a key energy source for colonocytes and is produced by the gut microbiota
through fermentation of dietary fiber. Butyrate is a histone deacetylase inhibitor and also …

A review of gut microbiota‐derived metabolites in tumor progression and cancer therapy

Q Yang, B Wang, Q Zheng, H Li, X Meng… - Advanced …, 2023 - Wiley Online Library
Gut microbiota‐derived metabolites are key hubs connecting the gut microbiome and cancer
progression, primarily by remodeling the tumor microenvironment and regulating key …

Lipid metabolism in T cell signaling and function

SA Lim, W Su, NM Chapman, H Chi - Nature chemical biology, 2022 - nature.com
T cells orchestrate adaptive immunity against pathogens and other immune challenges, but
their dysfunction can also mediate the pathogenesis of cancer and autoimmunity. Metabolic …

A mechanism by which gut microbiota elevates permeability and inflammation in obese/diabetic mice and human gut

SP Mishra, B Wang, S Jain, J Ding, J Rejeski… - Gut, 2023 - gut.bmj.com
Objective Ample evidence exists for the role of abnormal gut microbiota composition and
increased gut permeability ('leaky gut') in chronic inflammation that commonly co-occurs in …

Clostridioides difficile infection: history, epidemiology, risk factors, prevention, clinical manifestations, treatment, and future options

S Di Bella, G Sanson, J Monticelli… - Clinical Microbiology …, 2024 - journals.asm.org
Clostridioides difficile infection (CDI) is one of the major issues in nosocomial infections.
This bacterium is constantly evolving and poses complex challenges for clinicians, often …

Multi-omics analyses of radiation survivors identify radioprotective microbes and metabolites

H Guo, WC Chou, Y Lai, K Liang, JW Tam, WJ Brickey… - Science, 2020 - science.org
INTRODUCTION The toxicity of high-dose ionizing radiation is associated with the induction
of both chronic and acute radiation syndromes that occur after partial or total body radiation …

Lachnospiraceae-derived butyrate mediates protection of high fermentable fiber against placental inflammation in gestational diabetes mellitus

S Huang, J Chen, Z Cui, K Ma, D Wu, J Luo, F Li… - Science …, 2023 - science.org
Inflammation-associated insulin resistance is a key trigger of gestational diabetes mellitus
(GDM), but the underlying mechanisms and effective interventions remain unclear. Here, we …