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Neuroimaging standards for research into small vessel disease—advances since 2013
Cerebral small vessel disease (SVD) is common during ageing and can present as stroke,
cognitive decline, neurobehavioural symptoms, or functional impairment. SVD frequently …
cognitive decline, neurobehavioural symptoms, or functional impairment. SVD frequently …
Roles of transposable elements in the regulation of mammalian transcription
Transposable elements (TEs) comprise about half of the mammalian genome. TEs often
contain sequences capable of recruiting the host transcription machinery, which they use to …
contain sequences capable of recruiting the host transcription machinery, which they use to …
Genome-wide association studies
Genome-wide association studies (GWAS) test hundreds of thousands of genetic variants
across many genomes to find those statistically associated with a specific trait or disease …
across many genomes to find those statistically associated with a specific trait or disease …
Transforming Cardiovascular Care With Artificial Intelligence: From Discovery to Practice: JACC State-of-the-Art Review
Artificial intelligence (AI) has the potential to transform every facet of cardiovascular practice
and research. The exponential rise in technology powered by AI is defining new frontiers in …
and research. The exponential rise in technology powered by AI is defining new frontiers in …
Machine learning for multi-omics data integration in cancer
Multi-omics data analysis is an important aspect of cancer molecular biology studies and
has led to ground-breaking discoveries. Many efforts have been made to develop machine …
has led to ground-breaking discoveries. Many efforts have been made to develop machine …
Current trends, limitations and future research in the fungi?
The field of mycology has grown from an underappreciated subset of botany, to a valuable,
modern scientific discipline. As this field of study has grown, there have been significant …
modern scientific discipline. As this field of study has grown, there have been significant …
Enhancer redundancy in development and disease
Shadow enhancers are seemingly redundant transcriptional cis-regulatory elements that
regulate the same gene and drive overlap** expression patterns. Recent studies have …
regulate the same gene and drive overlap** expression patterns. Recent studies have …
The Singapore national precision medicine strategy
Precision medicine promises to transform healthcare for groups and individuals through
early disease detection, refining diagnoses and tailoring treatments. Analysis of large-scale …
early disease detection, refining diagnoses and tailoring treatments. Analysis of large-scale …
PhenoScore quantifies phenotypic variation for rare genetic diseases by combining facial analysis with other clinical features using a machine-learning framework
Several molecular and phenotypic algorithms exist that establish genotype–phenotype
correlations, including facial recognition tools. However, no unified framework that …
correlations, including facial recognition tools. However, no unified framework that …
Analysis of clinically relevant variants from ancestrally diverse Asian genomes
Asian populations are under-represented in human genomics research. Here, we
characterize clinically significant genetic variation in 9051 genomes representing East …
characterize clinically significant genetic variation in 9051 genomes representing East …