Engineered human blood–brain barrier microfluidic model for vascular permeability analyses
The blood–brain barrier (BBB) greatly restricts the entry of biological and engineered
therapeutic molecules into the brain. Due to challenges in translating results from animal …
therapeutic molecules into the brain. Due to challenges in translating results from animal …
Microfluidics in vascular biology research: a critical review for engineers, biologists, and clinicians
G Simitian, M Virumbrales-Muñoz… - Lab on a Chip, 2022 - pubs.rsc.org
Neovascularization, the formation of new blood vessels, has received much research
attention due to its implications for physiological processes and diseases. Most studies …
attention due to its implications for physiological processes and diseases. Most studies …
A neurovascular-unit-on-a-chip for the evaluation of the restorative potential of stem cell therapies for ischaemic stroke
The therapeutic efficacy of stem cells transplanted into an ischaemic brain depends primarily
on the responses of the neurovascular unit. Here, we report the development and …
on the responses of the neurovascular unit. Here, we report the development and …
A predictive microfluidic model of human glioblastoma to assess trafficking of blood–brain barrier-penetrant nanoparticles
The blood–brain barrier represents a significant challenge for the treatment of high-grade
gliomas, and our understanding of drug transport across this critical biointerface remains …
gliomas, and our understanding of drug transport across this critical biointerface remains …
Endothelial regulation of drug transport in a 3D vascularized tumor model
Drug discovery and efficacy in cancer treatments are limited by the inability of pre‐clinical
models to predict successful outcomes in humans. Limitations remain partly due to their lack …
models to predict successful outcomes in humans. Limitations remain partly due to their lack …
Omentum-on-a-chip: A multicellular, vascularized microfluidic model of the human peritoneum for the study of ovarian cancer metastases
Epithelial ovarian cancer has the highest mortality rate of any gynecologic malignancy and
most frequently metastasizes to the peritoneal cavity. Intraperitoneal metastases are highly …
most frequently metastasizes to the peritoneal cavity. Intraperitoneal metastases are highly …
Physiologic flow-conditioning limits vascular dysfunction in engineered human capillaries
Hemodynamics play a central role in the health and disease of the coronary and peripheral
vascular systems. Vessel-lining endothelial cells are known mechanosensors, responding to …
vascular systems. Vessel-lining endothelial cells are known mechanosensors, responding to …
The cancer glycocalyx mediates intravascular adhesion and extravasation during metastatic dissemination
The glycocalyx on tumor cells has been recently identified as an important driver for cancer
progression, possibly providing critical opportunities for treatment. Metastasis, in particular …
progression, possibly providing critical opportunities for treatment. Metastasis, in particular …
[HTML][HTML] On-chip recapitulation of the tumor microenvironment: A decade of progress
One of the hurdles to the development of new anticancer therapies is the lack of in vitro
models which faithfully reproduce the in vivo tumor microenvironment (TME). Understanding …
models which faithfully reproduce the in vivo tumor microenvironment (TME). Understanding …
Modeling early pathophysiological phenotypes of diabetic retinopathy in a human inner blood-retinal barrier-on-a-chip
TL Maurissen, AJ Spielmann, G Schellenberg… - Nature …, 2024 - nature.com
Diabetic retinopathy (DR) is a microvascular disorder characterized by inner blood-retinal
barrier (iBRB) breakdown and irreversible vision loss. While the symptoms of DR are known …
barrier (iBRB) breakdown and irreversible vision loss. While the symptoms of DR are known …