Network abnormalities and interneuron dysfunction in Alzheimer disease

JJ Palop, L Mucke - Nature Reviews Neuroscience, 2016 - nature.com
The function of neural circuits and networks can be controlled, in part, by modulating the
synchrony of their components' activities. Network hypersynchrony and altered oscillatory …

Current and future directions of deep brain stimulation for neurological and psychiatric disorders: JNSPG 75th Anniversary Invited Review Article

DJ Lee, CS Lozano, RF Dallapiazza… - Journal of neurosurgery, 2019 - thejns.org
Deep brain stimulation (DBS) has evolved considerably over the past 4 decades. Although it
has primarily been used to treat movement disorders such as Parkinson's disease, essential …

[HTML][HTML] Multi-sensory gamma stimulation ameliorates Alzheimer's-associated pathology and improves cognition

AJ Martorell, AL Paulson, HJ Suk, F Abdurrob… - Cell, 2019 - cell.com
We previously reported that inducing gamma oscillations with a non-invasive light flicker
(gamma entrainment using sensory stimulus or GENUS) impacted pathology in the visual …

The evolution of preclinical Alzheimer's disease: implications for prevention trials

R Sperling, E Mormino, K Johnson - Neuron, 2014 - cell.com
As the field begins to test the concept of a" preclinical" stage of neurodegenerative disease,
when the pathophysiological process has begun in the brain, but clinical symptoms are not …

Cascading network failure across the Alzheimer's disease spectrum

DT Jones, DS Knopman, JL Gunter, J Graff-Radford… - Brain, 2016 - academic.oup.com
Complex biological systems are organized across various spatiotemporal scales with
particular scientific disciplines dedicated to the study of each scale (eg genetics, molecular …

[HTML][HTML] Alzheimer mechanisms and therapeutic strategies

Y Huang, L Mucke - Cell, 2012 - cell.com
There are still no effective treatments to prevent, halt, or reverse Alzheimer's disease, but
research advances over the past three decades could change this gloomy picture. Genetic …

The cognitive neuroscience of ageing

C Grady - Nature Reviews Neuroscience, 2012 - nature.com
The availability of neuroimaging technology has spurred a marked increase in the human
cognitive neuroscience literature, including the study of cognitive ageing. Although there is a …

Connected speech and language in mild cognitive impairment and Alzheimer's disease: A review of picture description tasks

KD Mueller, B Hermann, J Mecollari… - Journal of clinical and …, 2018 - Taylor & Francis
Introduction: The neuropsychological profile of people with mild cognitive impairment (MCI)
and Alzheimer's disease (AD) dementia includes a history of decline in memory and other …

Functional magnetic resonance imaging, deep learning, and Alzheimer's disease: A systematic review

SL Warren, AA Moustafa - Journal of Neuroimaging, 2023 - Wiley Online Library
Alzheimer's disease (AD) is currently diagnosed using a mixture of psychological tests and
clinical observations. However, these diagnoses are not perfect, and additional diagnostic …

Brain imaging in Alzheimer disease

KA Johnson, NC Fox… - Cold Spring …, 2012 - perspectivesinmedicine.cshlp.org
Imaging has played a variety of roles in the study of Alzheimer disease (AD) over the past
four decades. Initially, computed tomography (CT) and then magnetic resonance imaging …